| association of p2x7 receptor +1513 (a-->c) polymorphism with tuberculosis in a punjabi population. | development of tuberculosis (tb) disease is an outcome of complex host-pathogen interactions. the purinergic p2x(7) receptors are adenosine triphosphate gated molecules shown to induce killing of intracellular mycobacterium tuberculosis, followed by apoptosis of the infected macrophage. a single nucleotide polymorphism in exon 13 of the p2x(7) receptors gene at +1513 position has been shown to abolish the function of this receptor and to be associated with increased susceptibility to tb in some ... | 2010 | 20819262 |