| epstein-barr-specific iga in nasopharyngeal cancer. | | 1978 | 78104 |
| nasopharyngeal carcinoma. ix. antibodies to ebna and correlation with response to other ebv antigens in chinese patients. | ninety-five sera from chinese npc patients in different stages of the disease, 38 sera from chinese patients with other cancers, and 50 normal chinese sera, were titrated for ebna, vca, ea and complement-fixing (cf/s) ebv-specific antibodies. the geometric mean (gmt) ebna antibody titre of patients with npc at stage i was found to be four times higher than that of normal individuals and increased in parallel with clinical deterioration. antibody titres against ebna did not correlate with either ... | 1975 | 171226 |
| descriptive and analytical epidemiology of nasopharyngeal cancer. | information concerning the descriptive and analytical epidemiology of npc that has been reported mainly since the first international symposium on the subject in singapore in 1964 are reviewed. npc is rare in most countries in the world, with an age-adjusted incidence rate of less than 1 per 100,000, and the incidence rate is twice as high in males as in females. chinese of southern origin have a uniquely high risk, the incidence rates per 100,000 being 10--20 in males and 5--10 in females. the ... | 1978 | 215514 |
| detection of epstein-barr virus in hodgkin's disease occurring in an oriental population. | like burkitt's lymphoma, the strength of association of epstein-barr virus (ebv) with hodgkin's disease occurring in different populations and clinical settings is highly variable, being 30% to 50% in western countries, nearly 100% in third world countries like peru and honduras, and nearly 100% in patients seropositive for human immunodeficiency virus. data on the oriental populations are very limited. therefore, the current study was performed on the chinese population of hong kong, where the ... | 1995 | 7890284 |
| epstein-barr virus-associated gastric lymphoma in hong kong chinese. | we report 11 cases of gastric lymphoma that harbor the epstein-barr virus (ebv) encoded small messenger rna, eber-1, detected by in situ hybridization. the cases represented 18% of 61 consecutive gastric lymphomas from three institutions in hong kong between 1988 and 1993. the mean age of patients was 62 years (range, 33 to 87). the male to female ratio was 5:6. nine of the 11 (81.8%) eber-1+ gastric lymphomas were diffuse large cell lymphomas of b-cell type without low grade components. macrosc ... | 1994 | 8088772 |
| detection of epstein-barr viral rna in sinonasal undifferentiated carcinoma from western and asian patients. | undifferentiated carcinoma of the nasopharynx has a well-known association with epstein-barr virus (ebv), but only an inconsistent relationship has been identified in undifferentiated carcinomas occurring at other sites. we investigated 22 formalin-fixed, paraffin-embedded cases of sinonasal undifferentiated carcinomas (snucs) occurring in western and asian patients. a highly sensitive in situ hybridization method was performed using an antisense oligonucleotide probe to the eber1 gene of ebv. w ... | 1994 | 7511355 |
| prevalence of lmp1 deletion variant of epstein-barr virus in nasopharyngeal carcinoma and gastric tumors in hong kong. | | 1996 | 8647637 |
| absence of epstein-barr virus in penile carcinoma. a study of 42 cases using in situ hybridization. | the relationship between epstein-barr virus (ebv) and carcinomas of the lower female genital tract has been the focus of some studies in recent years. however, the association between ebv and penile carcinoma never has been investigated. the aim of this study was to identify the possible role of ebv in penile carcinoma of chinese patients. | 1995 | 8625161 |
| lymphoepithelial carcinoma of the salivary gland: in situ detection of epstein-barr virus. | to examine the role of epstein-barr virus (ebv) in lymphoepithelial carcinoma of the salivary gland in hong kong chinese. | 1995 | 8543624 |
| nonnasal lymphoma expressing the natural killer cell marker cd56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm. | expression of the natural killer (nk) cell antigen cd56 is uncommon among lymphomas, and those that do are almost exclusively of non-b-cell lineage and show a predilection for the nasal and nasopharyngeal region. this study analyzes 49 cases of nonnasal cd56+ lymphomas, the largest series to date, to characterize the clinicopathologic spectrum of these rare neoplasms. all patients were chinese. four categories could be delineated. (1) nasal-type nk/t cell lymphoma (n = 34) patients were adults 2 ... | 1997 | 9192774 |
| prevalence of mutations and 30-bp deletion in the c-terminal region of epstein-barr virus latent membrane protein-1 oncogene in reactive lymphoid tissue and non-nasopharyngeal ebv-associated carcinomas in hong kong chinese. | a specific variant of epstein-barr virus (ebv) with a 30-bp deletion in the c-terminal region of the lmp1 gene has been found in some ebv-associated malignancies. to better understand the tumorigenic role of this lmp1 variant, we used pcr and sequencing to examine the lmp1 gene in 38 ebv-associated carcinomas (ebv-cas) occurring in various organs (6 lung, 10 salivary gland, 5 sino-nasal, 16 gastric and 1 metastatic npc), 55 reactive lymphoid tissues from tonsils (ton) and 67 ebv-negative tumours ... | 1997 | 9219824 |
| epstein-barr virus latent membrane protein 1 (lmp1) upregulates id1 expression in nasopharyngeal epithelial cells. | nasopharyngeal carcinoma is closely associated with epstein-barr virus (ebv) infection. the ebv-encoded lmp1 has cell transformation property. it suppresses cellular senescence and enhances cell survival in various cell types. many of the downstream events of lmp1 expression are mediated through its ability to activate nf-kappab. in this study, we report a novel function of lmp1 to induce id1 expression in nasopharyngeal epithelial cells (np69) and human embryonal kidney cells (hek293). the id1 ... | 2004 | 15064751 |
| nasopharyngeal carcinoma research in hong kong in the past decade. | to review the research carried out in hong kong on nasopharyngeal carcinoma (npc) over the past 10 years. | 1997 | 9772411 |
| ebv specific antibody-based and dna-based assays in serologic diagnosis of nasopharyngeal carcinoma. | we assessed 5 ebv specific assays for their capacity to effect serologic diagnosis of suspected npc. the assays were the immunofluorescent assays, vca iga and ea iga, the enzyme-linked immunosorbent assays specific for ebna 1 iga or zta igg and an ebv dna assay. serum samples were taken from 218 symptomatic npc patients presenting consecutively at a public hospital in hong kong, 51 of whom were subsequently diagnosed as having npc; 4 had ebv-associated lung cancer with similar serology as npc. t ... | 2003 | 12740922 |
| identification of serum amyloid a protein as a potentially useful biomarker to monitor relapse of nasopharyngeal cancer by serum proteomic profiling. | nasopharyngeal cancer (npc) is a common cancer in hong kong, and relapse can occur frequently. using protein chip profiling analysis, we aimed to identify serum biomarkers that were useful in the diagnosis of relapse in npc. experimental design: profiling analysis was performed on 704 sera collected from 42 npc patients, 39 lung cancer patients, 30 patients with the benign metabolic disorder thyrotoxicosis (tx), and 35 normal individuals (nm). protein profile in each npc patient during clinical ... | 2004 | 14734450 |
| distinct epidermal growth factor receptor and kras mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. | this study evaluated the mutational profile of epidermal growth factor receptor (egfr) and kras in non-small cell lung cancers in hong kong and determined their relation with smoking history and other clinicopathologic features. | 2006 | 16533793 |
| prevalence of human papillomavirus, epstein-barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in hong kong patients. | background: the purpose of this study of human papillomavirus (hpv), epstein-barr virus (ebv), p21, and p53 in sinonasal inverted papilloma (ip) was to help elucidate its pathogenesis. methods: seventy-three ips, 48 nasal polyps, and 85 hypertrophied turbinates were subjected to hpv polymerase chain reaction (pcr) study. seventy-three ips, 30 nasal polyps, and 32 hypertrophied turbinates were subjected to ebv in situ hybridization (ish), p21, and p53 immunohistochemical (ihc) studies. results: h ... | 2011 | 21608063 |
| salivary epstein-barr virus dna level in patients with nasopharyngeal carcinoma following radiotherapy. | nasopharyngeal carcinoma (npc) is a solid tumor closely associated with epstein-barr virus (ebv) infection. the purpose of this investigation was to detect and quantify the ebv dna level in salivary samples of npc patients following treatment using real-time pcr. a total of 175 consecutive newly diagnosed npc patients' whole saliva samples were collected before treatment, and the ebv dna level was measured by real-time pcr, with the primers and probe targeting the bamhi-w region of the ebv genom ... | 2011 | 21767975 |