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antibody to epstein-barr virus-specific dnase as a marker for field survey of patients with nasopharyngeal carcinoma in taiwan.a serological survey using antibody to epstein-barr virus (ebv)-specific dnase activity as a marker for the identification of patients with nasopharyngeal carcinoma (npc) has been carried out on healthy subjects who visited government employees' clinic center (gecc) for routine health examination and on individuals residing in npc high-risk areas (hra) in taiwan. during a 3-year prospective study, 22,596 and 9,869 sera were collected from the gecc and hra groups, respectively. taking neutralizat ...19892542436
antibodies to epstein-barr virus in a burkitt's lymphoma cell line in taiwan monkeys (macaca cyclopis).the prevalence of taiwan monkeys with antibodies to epstein-barr virus, as detected by the indirect immunofluorescence technique, was lower than that of healthy persons in taiwan.19714324196
antibodies to herpes-type virus in nasopharyngeal carcinoma and control groups. 19724334237
genomic analysis of epstein-barr virus in nasal and peripheral t-cell lymphoma: a comparison with nasopharyngeal carcinoma in an endemic area.the epstein-barr virus (ebv) is prevalent in nasal and peripheral t-cell lymphoma (nptl) in taiwan, where nasopharyngeal carcinoma (npc) is endemic. in order to understand the pathogenesis of these two malignancies in this endemic area, genomic analysis of ebv in nptl with comparison to npc is important. we investigated the ebv subtype (types a and b), bamh-i "f" variant, and the xho-i site mutant of the latent membrane protein-1 (lmp-1) gene in 19 cases of ebv-associated nptl and in 30 cases of ...19968950688
association between epstein-barr virus and burkitt's lymphoma in taiwan.the association between epstein-barr virus (ebv) and burkitt's lymphoma (bl) in taiwan is not clear. in this study, the authors attempted to determine the frequency of the occurrence of ebv infection in patients with bl in taiwan.19979210717
association of hla class i and ii alleles and extended haplotypes with nasopharyngeal carcinoma in taiwan.nasopharyngeal carcinoma (npc), which occurs at a disproportionately high rate among chinese individuals, is associated with epstein-barr virus (ebv). human leukocyte antigen (hla) polymorphisms appear to play a role in npc, because they are essential in the immune response to viruses. we used high-resolution hla genotyping in a case-control study in taiwan to systematically evaluate the association between various hla alleles and npc.200212464650
association of viral factors with non-familial breast cancer in taiwan by comparison with non-cancerous, fibroadenoma, and thyroid tumor tissues.to study the etiologic factors of non-familial breast cancer, the polymerase chain reaction (pcr) and southern hybridization were used to detect six viruses including human papillomavirus (hpv), cytomegalovirus (cmv), epstein-barr virus (ebv), herpes simplex virus (hsv)-1, hsv-2, and human herpesvirus (hhv)-8 dna in 69 patients with breast cancer and 60 specimens from non-cancerous or other individuals with thyroid tumors or fibroadenoma (non-breast cancer controls). two specimens from patients ...200515602723
childhood macrophage activation syndrome differs from infection-associated hemophagocytosis syndrome in etiology and outcome in taiwan.hemophagocytic lymphohistiocytosis (hlh) is a syndrome composed of macrophage activation syndrome (mas), infection-associated hemophagocytosis syndrome (iahs), malignancy-associated hlh and genetic hlh. differentiation of mas from iahs and other hlh is important for early appropriate treatment.200717639169
distribution and prognosis of who lymphoma subtypes in taiwan reveals a low incidence of germinal-center derived tumors.to assess the distribution of lymphomas in taiwan according to the who (world health organization) classification, 175 recently diagnosed cases of malignant lymphomas were studied and the clinicopathologic data were analyzed. b-cell lymphomas accounted for 57.1% of cases, t-cell lymphomas 38.9%, and hodgkin's lymphoma 4%. extranodal lymphomas predominated (55.4%). the most common subtype of b-cell lymphoma was diffuse large b-cell lymphoma (33.1%). all tumor types believed to be derived from ger ...200415359636
t-cell and nk/t-cell lymphomas in southern taiwan: a study of 72 cases in a single institute.in an attempt to better understand the clinicopathologic features of t- and natural killer (nk)/t-cell lymphomas in taiwan and the distribution and relative frequency of each subtype according to the new who classification, the pathology file of a medical center in southern taiwan during 1989-2002 was retrospectively searched. the results of light microscopy, immunohistochemistry, in situ hybridization for epstein-barr virus (eber), and t-cell receptor (tcr)-gamma chain gene rearrangement were c ...200415291350
screening nasopharyngeal carcinoma by detection of the latent membrane protein 1 (lmp-1) gene with nasopharyngeal swabs.nasopharyngeal carcinoma (npc) is a common head and neck cancer in taiwan. the goals of the current study were to investigate whether a nasopharyngeal swab technique could provide enough dna for polymerase chain reaction (pcr) analysis of the epstein-barr virus (ebv)-derived latent membrane protein 1 (lmp-1) gene and to determine the feasibility and reliability of diagnosing npc by detection of lmp-1 in the nasopharynx.200312673717
serologic markers of epstein-barr virus infection and nasopharyngeal carcinoma in taiwanese men.it is probable but unproven that epstein-barr virus (ebv) has a role in nasopharyngeal carcinoma. we determined whether antibodies against ebv are present before the development of nasopharyngeal carcinoma.200111756578
clonal disease of natural killer large granular lymphocytes in taiwan.lymphoproliferative diseases of large granular lymphocytes (ldgl) may arise from either cd3+ t cells or cd3- natural killer (nk) cells. ldgl with clonal proliferation of large granular lymphocytes (lgl) is defined as lgl leukaemia. the number of patients with nk-lgl leukaemia reported is limited and the pathogenesis of the disease is not yet clear. from 1991 to 1998 six patients with cytogenetically proved clonal disease of nk-lgl were identified in our institute. all were seropositive for epste ...19989886330
expression of epstein-barr virus in carcinomas of major salivary glands: a strong association with lymphoepithelioma-like carcinoma.to elucidate the role of epstein-barr virus (ebv) in salivary gland carcinomas, 56 cases of carcinomas of major salivary glands were investigated. these included 14 mucoepidermoid carcinomas, 13 adenoid cystic carcinomas, seven malignant mixed tumors, four adenocarcinomas, four salivary duct carcinomas, two acinic cell carcinomas, two undifferentiated carcinomas without lymphoid stroma, seven lymphoepithelioma-like carcinomas (lelcs), two squamous cell carcinomas, and one small cell carcinoma. e ...19968600040
a pathologic study of childhood lymphoma in taiwan with special reference to peripheral t-cell lymphoma and the association with epstein-barr viral infection.the authors retrospectively reviewed the clinicopathologic and immunologic features of 65 consecutive cases of childhood lymphoma reported between 1980 and 1989. southern blot hybridization was also performed in 23 cases to study their association with epstein-barr virus (ebv) and human t-cell leukemia virus type 1 (htlv-1). the 65 cases included 56 non-hodgkin's lymphoma (nhl) (86%) and 9 hodgkin's disease (hd) (14%). the nhl could be classified into the following groups: group i, small nonclea ...19911655230
fireside conference 16. nasopharyngeal carcinoma. 19921327018
auto-antibodies in the sera of patients with nasopharyngeal carcinoma. 1975191369
primary lymphoepithelioma-like carcinoma of minor salivary gland: a case report with immunohistochemical and in situ hybridization studies.lymphoepithelioma-like carcinomas (lec) of salivary glands represent rare epithelial malignancies, with most cases affecting the parotid gland. to our knowledge, there was only one lec arising from the minor salivary gland described in the english-language literature.200616240326
nasal nk/t cell lymphoma in taiwan: a clinicopathologic study of 22 cases, with analysis of histologic subtypes, epstein-barr virus lmp-1 gene association, and treatment modalities.nasal nk/t cell lymphoma is a distinctive type of extranodal lymphoma with an unique immunophenotype and a strong association with epstein-barr virus (ebv). it is one of the common extranodal lymphomas in taiwan. we studied 22 cases of nasal nk/t cell lymphoma to characterize their clinicopathologic features and to explore the possible differences between histologic subtypes and their clinical behavior as well as the prevalence of 30-base pair (bp) deleted latent membrane protein-1 (lmp-1) gene ...200415494863
detecting epstein-barr virus dna from peripheral blood mononuclear cells in adult patients with systemic lupus erythematosus in taiwan.epstein-barr virus (ebv) has been found by many serology studies to be associated with systemic lupus erythematosus (sle). however, the results of dna studies have been conflicting. therefore, instead of antibody to ebv, we studied the association between ebv dna and sle. in this case-control study in taiwan, we enrolled 87 sle patients and 174 age- and sex-matched controls. peripheral blood mononuclear cells of sle patients and matched controls were tested for ebv dna by polymerase chain reacti ...200515378356
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