| recent emergence of new variants of yersinia pestis in madagascar. | yersinia pestis, the causative agent of plague, has been responsible for at least three pandemics. during the last pandemic, which started in hong kong in 1894, the microorganism colonized new, previously unscathed geographical areas where it has become well established. the aim of this longitudinal study was to investigate the genetic stability of y. pestis strains introduced into a new environment just under a century ago and to follow the epidemiology of any new genetic variant detected. in t ... | 1997 | 9350742 |
| [update on plague in madagascar]. | after a thirty year period of successful control, bubonic plague showed the first signs of return in madagascar where a fatal outbreak occurred in antananarivo in 1978. a second outbreak was observed in mahajanga in 1991 after more than a half century. in 1997, 459 confirmed or presumptive cases were reported, as compared to 150 to 250 cases during the last years. however the actual extent of this recrudescence must be placed in the perspective of a more efficient control program that has led to ... | 1998 | 9812306 |
| [the plague at the tsenabe isotry market in antananarivo: a complex epidemiologic situation]. | the transmission of yersinia pestis is intense among rats in the wholesale market tsenabe isotry in the capital antananarivo (anti-f1 sero-prevalence 80%, flea index 8.4 for a cut-off risk index of > 1). however, the number of plague-suspected (not laboratory confirmed) human cases has only been 3 in this district during a four years period from 1995 to 1999. a seroepidemiological survey among the market vendors was undertaken in june 1999 to test the hypothesis that the low incidence of human p ... | 2001 | 12471741 |
| phylogeography and molecular epidemiology of yersinia pestis in madagascar. | plague was introduced to madagascar in 1898 and continues to be a significant human health problem. it exists mainly in the central highlands, but in the 1990s was reintroduced to the port city of mahajanga, where it caused extensive human outbreaks. despite its prevalence, the phylogeography and molecular epidemiology of y. pestis in madagascar has been difficult to study due to the great genetic similarity among isolates. we examine island-wide geographic-genetic patterns based upon whole-geno ... | 2011 | 21931876 |