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comparison of closely related orthopoxvirus isolates by random amplified polymorphic dna and restriction fragment length polymorphism analysis.the reliability and reproducibility of random amplified polymorphic dna analysis (rapd) was compared with restriction fragment length polymorphism (rflp) by analysing three virus strains isolated from zoo animals in berlin and three isolates which were cultivated from pets from northern germany. the rapd technique was evaluated as a reliable tool with good reproducibility of the patterns for each virus strain investigated. problems of interpretation due to inconsistent intensity of bands in diff ...200111765800
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