| potential transmission of viral hepatitis through use of stored blood vessels as conduits in organ transplantation-pennsylvania, 2009. | | 2011 | 21446983 |
| effects of hepatitis c-induced liver fibrosis on survival in kidney transplant candidates. | we sought to investigate survival among kidney transplant candidates with varying degrees of liver fibrosis. we studied 108 patients with hepatitis c+ who underwent pre-kidney transplant liver biopsy (1992-2004). eighteen patients had advanced fibrosis (bridging fibrosis or cirrhosis), and 90 had lesser degrees of fibrosis. advanced fibrosis patients were younger and had lower prevalence of diabetes. survival was similar between those with and without advanced fibrosis among all 108 patients (p ... | 2007 | 17394069 |
| the oklahoma-pittsburgh experience with interferon alpha in the treatment of hcv disease. | interferon alpha (ifn) is the only food and drug administration (fda)-approved therapy available for the treatment of chronic hepatitis c. the ideal dose and frequency of ifn administration that produces the greatest number of patient responders with the least number of relapses following drug withdrawal remains unclear. methods. one hundred seventeen patients recruited over a five-year period with chronic hepatitis c were divided into four groups and treated with progressively larger doses. the ... | 1995 | 7782963 |
| aggressive use of ribavirin and prolonged course of peginterferon to improve the rate of viral response in liver transplant patients with recurrent hepatitis c viral infection. | there are different approaches for treating recurrent hepatitis c viral infection after a liver transplant. however, sustained virologic response is achieved in < 40% of infected allografts. we examined sustained virologic response improvement using a prolonged course of peginterferon and aggressive use of ribavirin. | 2010 | 20716039 |
| prevalence of hepatitis c infection in health care workers affiliated with a liver transplant center. | the risk of hepatitis c to liver transplantation health care workers has not been identified. we compared the occupational risk of hepatitis c in health care workers associated with liver transplantation with risk of health care workers affiliated with the same institutions but not involved in transplantations. health care workers were recruited from 2 transplant centers. participation was voluntary; results were confidential. an occupational and health history questionnaire was completed and bl ... | 1995 | 7535961 |
| potential transmission of viral hepatitis through use of stored blood vessels as conduits in organ transplantation--pennsylvania, 2009. | solid organ transplantation sometimes requires the use of blood vessels from a deceased donor as conduits to connect transplanted organ vessels to recipient vessels. vessels not immediately used are sometimes stored for later use, including vessels collected from hepatitis b virus (hbv) and hepatitis c virus (hcv) seropositive donors; hbv and hcv seropositive vessels can be stored for use in seropositive recipients. in may 2009, hcv was transmitted when a transplant facility inadvertently used a ... | 2011 | 21330966 |
| functional restoration of hcv-specific cd8 t cells by pd-1 blockade is defined by pd-1 expression and compartmentalization. | the immunoinhibitory receptor programmed death-1 (pd-1) is up-regulated on dysfunctional virus-specific cd8 t cells during chronic viral infections, and blockade of pd-1/pd-ligand (pd-l) interactions can restore their function. as hepatitis c virus (hcv) persists in the liver with immune-mediated disease pathogenesis, we examined the role of pd-1/pd-l pathway in antigen-specific cd8 t-cell dysfunction in the liver and blood of hcv-infected patients. | 2008 | 18549878 |