| adverse outcomes in alaska natives who recovered from or have chronic hepatitis c infection. | the factors associated with adverse outcome from hepatitis c virus (hcv) infection are incompletely understood. to determine the incidence and risk factors associated with the development of end-stage liver disease (esld) and liver-related death (lrd), we conducted a retrospective/prospective population-based study in a cohort of alaska native persons chronically infected with hcv from 1994 to 2005. | 2010 | 19909749 |
| clinical significance of elevated alpha-fetoprotein in alaskan native patients with chronic hepatitis c. | the clinical significance of elevated serum alpha-fetoprotein (afp) in patients with chronic hepatitis c virus (hcv) infection is not well defined. we analysed data from a population-based cohort of patients with hcv infection to assess the prevalence of elevated serum afp, to determine its association with clinical and virologic parameters and with clinical outcomes. we defined a slightly elevated serum afp level as 8 to <15 and a high-afp level as > or =15 microg/l. among 541 hcv-rna-positive ... | 2008 | 18233991 |
| results of a general hepatitis c lookback program for persons who received blood transfusions in a neonatal intensive care unit between january 1975 and july 1992. | to notify persons who received a blood transfusion in a neonatal intensive care unit between january 1975 and july 1992 of their risk for hepatitis c infection and to encourage them to seek hepatitis c antibody testing. | 2007 | 17283296 |
| hepatitis c infection in alaska natives with persistently normal, persistently elevated or fluctuating alanine aminotransferase levels. | an estimated one-third of patients with chronic hepatitis c virus (hcv) infection have persistently normal alanine transaminase (pnalt); however, in many previous studies alanine aminotransferase (alt) levels were followed for < or = 12 months. | 2006 | 16842319 |
| high rate of spontaneous negativity for hepatitis c virus rna after establishment of chronic infection in alaska natives. | hepatitis c virus (hcv) leads to chronic infection in 70%-85% of exposed patients. spontaneous clearance of the virus after chronic infection is believed to occur rarely. | 2006 | 16511757 |
| results of a hepatitis c general transfusion lookback program for patients who received blood products before july 1992. | the centers for disease control and prevention recommend hepatitis c virus (hcv) antibody (anti-hcv) screening for persons who received blood products before july 1992. a general transfusion lookback program was implemented to identify, counsel, and screen persons who received transfusions at the alaska native medical center between january 1980 and july 1992. | 2005 | 15935002 |
| epidemiology and risk factors for hepatitis c in alaska natives. | large cohorts of persons infected with hepatitis c virus (hcv) that include patients with multiple risk exposures and behaviors have been rarely reported. we herein describe a population-based cohort of 759 alaska natives (an) with hcv who were recruited into a long-term follow-up study. history of injection drug use (idu) was reported by 60.1% and blood transfusion by 14.0%. the most common genotype was 1a (42.0%), followed by 1b (20.3%), 2b (14.7%), 3a (14.3%), and 2a (7.8%). by multivariable ... | 2004 | 14767985 |