| anti-hcv bioactivity of pseudoguaianolides from parthenium hispitum. | five new (1-5) and four known (6-9) c14-oxygenated 1alpha-hydroxy-11(13)-pseudoguaien-6beta,12-olides with potent inhibition of hepatitis c virus (hcv) replication were obtained from parthenium hispitum via high-throughput natural product chemistry methods. a semipreparative hplc system was used to purify these compounds. the miniaturization of the structure elucidation and dereplication for the mass-limited samples were performed primarily utilizing a capillary-scale nmr probe. compounds 2-4 we ... | 2007 | 17291045 |
| seroprevalence of viral hepatitis in an older nursing home population. | to assess the prevalence of current or previous infection with viral hepatitis agents in an older nursing home population. | 1999 | 10484255 |
| hepatitis c virus infection in non-hodgkin's lymphoma. | hepatitis c virus (hcv) infection is associated with immune-complex mediated disorders, including type ii mixed cryoglobulinaemia. mixed cryoglobulinaemia is itself a low-grade b-cell lymphoproliferative disorder which may progress to non-hodgkin's lymphoma (nhl). studies from europe and asia have found a prevalence of hepatitis c virus infection in non-hodgkin's lymphoma patients as high as 34%. other viral infections are also associated with non-hodgkin's lymphoma. we speculated that non-hodgk ... | 1998 | 9681221 |
| immunoassays to study prevalence of antibody against gb virus c in blood donors. | immunoassays were developed to determine the seroprevalence of antibody against human gb virus c (gbv-c). the antigenic target in each assay was a 44.6-kda glycosylated protein representing the first 315 amino acids encoded by the gbv-c e2 gene. sera or plasma were assayed for e2 antibody using an anti-human eia format in which antigen-coated polystyrene beads were reacted with sample, and bound antibody was detected by addition of enzyme labelled goat anti-human igg. the presence of anti-e2 ant ... | 1997 | 9395139 |
| application of six hepatitis c virus genotyping systems to sera from chronic hepatitis c patients in the united states. | serum samples from 139 us patients with chronic hepatitis c virus (hcv) infection were studied using six different genotyping systems, including both molecular and serologic methods, to determine the applicability of these approaches and the prevalence of various hcv subtypes. the concordance of genotyping results based on the various systems (except for core polymerase chain reaction genotyping) was good (93.5%). subtypes 1a and 1b were prevalent (37.4%). subtypes 2a (2.2%), 2b (8.6%), and 3a ( ... | 1995 | 7844363 |