| detection of three types of hepatitis c virus in blood donors: investigation of type-specific differences in serologic reactivity and rate of alanine aminotransferase abnormalities. | the serologic reactivity and epidemiology associated with different hepatitis c virus (hcv) variants were investigated in a cohort of 113 anti-hcv-positive donors. in scotland, hcv type 1 accounted for one-half of all infections; 40 percent of subjects were infected with hcv type 3, and the remainder were infected with type 2. reactivity with the ns-4-encoded antigens in the first-generation anti-c100 assay was absent in 68 percent of donors infected with types 2 and 3, as compared with 10 perce ... | 1993 | 7678709 |
| confirmation of hepatitis c virus antibody in blood donors. | of 103,203 donations collected in scotland and northern ireland over a 3-month period and screened for hcv antibody by ortho or abbott second-generation elisas, 340 were found repeatedly reactive. supplementary testing with riba-2 resulted in 77 being classified as positive, 130 as indeterminate, and 133 as negative. pcr analysis of the positives and indeterminates indicated viraemia in 65 (84%) of the positives and 7 (5.5%) of the indeterminates. to determine if pcr analysis could be eliminated ... | 1993 | 7505306 |