| a natural intergenotypic recombinant of hepatitis c virus identified in st. petersburg. | hepatitis c virus (hcv) evolution is thought to proceed by mutations within the six genotypes. here, we report on a viable spontaneous hcv recombinant and we show that recombination may play a role in the evolution of this virus. previously, 149 hcv strains from st. petersburg had been subtyped by limited sequencing within the ns5b region. in the present study, the core regions of 41 of these strains were sequenced to investigate the concordance of hcv genotyping for these two genomic regions. t ... | 2002 | 11907242 |
| [the verification of the results of screening antibodies to hepatitis c virus in blood donors]. | 6,744 persons were examined for the presence of antibodies to hepatitis c virus (hcv) before blood donation (4,219 persons in moscow and 2,525 persons in st. petersburg). the serum samples found to contain antibodies to hcv were additionally studied by the immunoblot techniques. the positive results of antibody screening were registered in 78 persons: 26 persons in moscow (0.62%) and 52 in st. petersburg (2.05%). in both cities the positive results of screening were confirmed in 62% of cases. di ... | 2005 | 16279540 |
| hepatitis c virus infection among drug injectors in st petersburg, russia: social and molecular epidemiology of an endemic infection. | to understand the epidemiology and transmission patterns of hepatitis c virus (hcv), the predominant blood borne-pathogen infecting injection drug users (idus), in a part of the former soviet union. | 2009 | 19712125 |
| full-length open reading frame of a recombinant hepatitis c virus strain from st petersburg: proposed mechanism for its formation. | the full-length orfs for the hepatitis c virus recombinant rf1_2k/1b (n687) and the non-recombinant 1b strain n589 were sequenced. a single recombination point was found and the sizes of the genes (c, e1, e2, p7, ns2, ns3, ns4 and ns5) were according to the parental subtypes. the pkr-eif2alpha phosphorylation site homology domain sequence of the e2 protein was identical to those of genotype 2 strains, while the ifn-alpha-sensitivity-determining region of the ns5a protein was identical to those o ... | 2004 | 15218169 |
| [genetic variations of hepatitis c virus circulating in the ural region]. | a study of distributions of different genetic variations (subtypes) of hepatitis c virus (hcv), circulating in the territories of yekaterinburg and chelyabinsk among infected population categories of different social statuses and age, is reported in the paper. the predominance of 1b subtype was shown in the hcv-infected patients at the hemodialysis center (hdc) and at the pediatric oncohematology center (ohc), 83.3% and 84.6% respectively. the summarized results of examinations of patients condu ... | 2003 | 14598474 |
| shift in predominating subtype of hcv from 1b to 3a in st. petersburg mediated by increase in injecting drug use. | the genotypes of 149 hcv strains from st. petersburg were determined by limited sequencing and phylogenetic analysis within the ns5b region. one hundred two strains derived from patients that attended infectious disease clinics, of whom 48 admitted injecting drug use, and 47 derived from dialysis patients. subtype 3a was predominant in the patients from infectious disease clinics, both in patients that admitted injecting drug use (56%) and in those with unknown source of infection (46%). however ... | 2001 | 11596087 |