| hepatitis c virus genotypes in singapore and indonesia. | 5' untranslated and partial core (c) region sequence of hepatitis c virus (hcv) in 21 singaporean and 15 indonesian isolates were amplified by reverse-transcription polymerase chain reaction and sequenced with the use of conserved primer sequences deduced from hcv genomes identified in other geographical regions. the hcv genotypes are predominantly that of simmonds type 1 and less of type 2 and 3 with the latter genotype currently not detected in indonesia. the 5' untranslated sequences are rela ... | 1995 | 7489348 |
| prevalence of antibodies to hepatitis c virus in relation to surrogate markers in a blood donor population of singapore. | prevalence of antibodies to hcv is studied among a blood donor population in singapore and its relationship to surrogate markers was examined. sequential serum samples from 4,091 blood donors were tested for the presence of anti-hcv using the second generation immunoassay (abbott). 275 random serum samples were tested for anti-hbc and alt. all the samples positive for anti-hcv were also tested for anti-hbc and alt. only 22 of the 4,091 donor samples (0.54%) were repeatedly reactive for anti-hcv. ... | 1993 | 7533946 |
| hepatitis c, e and g virus--three new viruses identified by molecular biology technique in the last decade. | the development of molecular biology techniques has enabled us to clone the genetic sequence of three new hepatitis viruses, namely, hepatitis c virus, hepatitis e virus and hepatitis g, or gbv-c virus in the last decade. hepatitis c virus (hcv) is now known to account for the majority of the parenterally transmitted non-a, non-b hepatitis and hepatitis e virus (hev) is the major cause of the epidemics of enterally transmitted non-a, non-b hepatitis in the less developed countries, mainly throug ... | 1997 | 9494678 |
| identification and molecular characterisation of the complete genome of a singapore isolate of hepatitis c virus: sequence comparison with other strains and phylogenetic analysis. | the complete genomic sequence of a singapore isolate of the hepatitis c virus (hcv) was obtained from serum of an individual chronically infected with hcv. nine overlapping cdna clones covering the entire viral genome was amplified by reverse-transcription-polymerase chain reaction (rt-pcr), this isolate (hcv-s1) comprised 9,609 nucleotides (nt), including 341 nt of the complete 5' untranslated region (5' utr), a single open reading frame of 3,011 amino acids (aa) and 235 nt of the complete 3' u ... | 2001 | 11556407 |
| seroprevalence of hepatitis c in intravenous opioid users presenting in the early phase of injecting drug use in singapore. | all over the world, hepatitis c virus (hcv) accounts for an estimated 130 million chronic infections. injection drug use has become one of the most important risk factors for hcv, and within the injection drug user population, the prevalence of hcv antibody ranges from 70 to 95 percent depending on an individual's length of use and the prevalence of infection in the community. this study was undertaken to determine the prevalence of and the risk factors for hepatitis c antibodies in injecting dr ... | 2007 | 17538746 |
| treatment of chronic hepatitis c in patients with end-stage renal disease and hemophilia--the singapore experience. | the aim of this study was to determine the response to treatment with interferon-alpha (ifn-alpha) in patients with chronic hepatitis c who had end-stage renal disease (esrd) or hemophilia in singapore. | 2006 | 16166798 |
| partial sequence analysis of the hepatitis c viral genome in singapore patients. | the distribution of hepatitis c viral (hcv) genotypes in singapore has not been previously determined. we studied the sera of 40 singapore patients which were pcr-positive for hcv. the hcv genotypes were determined by direct sequencing of amplified sequences of the 5' non-coding region, after reverse transcription. of the 40 samples, 35/40 (87.5%) were of hcv type 1, 2/40 (5.0%) were of type 2 and 3/40 (7.5%) were of type 3. the most common hcv genotype in this study was the type 1 genotype. our ... | 1994 | 8123037 |
| combinatorx brings its molecular speed dating to singapore. | | 2007 | 17939128 |