| prevalence of hepatitis c virus (hcv) infection and its vertical transmission in egyptian pregnant women and their newborns. | we studied the prevalence of hepatitis c virus (hcv) antibody seropositivity using elisa (ortho diagnostic system, 3rd generation test) polymerase chain reaction testing of hcv-rna (pcr, promega) and serum alanine transferase (alt) level in 100 healthy, hiv-negative, pregnant women who delivered spontaneously at the alexandria university hospital, and their newborns. some risk factors were studied using fisher's exact test. nineteen per cent of pregnant women were hcv seropositive and 14 of them ... | 2000 | 10996985 |
| in egyptians, a mutation in the lymphotoxin-alpha gene may increase susceptibility to hepatitis c virus but not that to schistosomal infection. | in egypt, human schistosomiasis is a chronic endemic disease that can produce portal hypertension and occasionally death. curiously, most egyptian cases of the disease are complicated by co-infection with hepatitis c virus (hcv), the co-infection generally resulting in more severe liver disease than seen in those only infected with hcv. the high frequency of co-infection may be the result of transmission of the virus during parental schistosomal therapy or schistosomiasis-related surgery but it ... | 2008 | 19000388 |
| molecular epidemiology of hepatitis c virus genotype 4 isolates in egypt and analysis of the variability of envelope proteins e1 and e2 in patients with chronic hepatitis. | we analyzed hepatitis c virus (hcv) genotype 4 isolates circulating in the alexandria district (egypt) in terms of genetic divergence and the presence of different subtypes. hypervariable region 1 (hvr1) and the nh2 region of the e2 protein were characterized, and the heterogeneity of subtype 4a isolates was evaluated by analyzing epitope frequencies, immunoproteasome prediction, and possible glycosylation patterns. the heterogeneity of the nucleotide sequences was greater than that found in pre ... | 2005 | 15815016 |