| ectopic overexpression of orexin alters sleep/wakefulness states and muscle tone regulation during rem sleep in mice. | orexins (also called hypocretins), which are neuropeptides exclusively expressed by a population of neurons specifically localized in the lateral hypothalamic area, are critically implicated in the regulation of sleep/wake states. orexin deficiency results in narcoleptic phenotype in rodents, dogs, and humans, suggesting that orexins are important for maintaining consolidated wakefulness states. however, the physiological effect of constitutive increased orexinergic transmission tone, which migh ... | 2011 | 20711757 |
| kidney and pancreas transplantation at wake forest university baptist medical center. | more than 1,100 transplants have been performed at wfubmc, including 60 pediatric transplants and 40 pancreas transplants. the one-year living donor kidney graft survival rate exceeds 90% and the 2 year deceased donor kidney graft survival rate exceeds 80%. the current active waiting list includes more than 300 candidates. despite more transplants being performed, we continue to under-serve our referral area, which has among the highest rates of hypertension, diabetes, and end stage renal diseas ... | 2003 | 15387115 |