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update: ebola-related filovirus infection in nonhuman primates and interim guidelines for handling nonhuman primates during transit and quarantine. 19902104655
detection and molecular characterization of ebola viruses causing disease in human and nonhuman primates.ebola (ebo) viruses were detected in specimens obtained during the hemorrhagic fever outbreak among humans in kikwit, democratic republic of the congo (drc), in 1995 (subtype zaire) and during an outbreak of disease in cynomolgus macaques in alice, texas, and the philippines in 1996 (subtype reston). reverse transcriptase-polymerase chain reaction assays were developed and proven effective for detecting viral rna in body fluids and tissues of infected individuals. little change was seen in the n ...19999988180
combined simian hemorrhagic fever and ebola virus infection in cynomolgus monkeys.simian hemorrhagic fever (shf) virus and a new strain of ebola virus were isolated concurrently in recently imported cynomolgus monkeys (macaca fascicularis) being maintained in a quarantine facility. ebola virus had never been isolated in the u.s. previously and was presumed to be highly pathogenic for humans. a chronology of events including measures taken to address the public health concerns is presented. the clinicopathologic features of the disease were abrupt anorexia, splenomegaly, marke ...19921318446
molecular characterization of an isolate from the 1989/90 epizootic of ebola virus reston among macaques imported into the united states.we have determined the entire genomic sequence of the pennsylvania strain, which was isolated along with the virginia strain during the emergence of ebola virus reston in 1989/90 in the united states. thus, either the pennsylvania or virginia strain, neither of which had been previously molecularly characterized, can be considered as the prototype for ebola virus reston. comparative analysis showed a high degree of homology to the concomitantly analyzed and recently published philippine strain o ...200212191779
ebola virus infection in imported primates--virginia, 1989. 19892511410
ebola virus infection in imported primates--united states.in late november 1989, ebola virus was isolated from cynomolgus monkeys (macaca fascicularis) imported into the united states from the philippines via amsterdam and new york. during quarantine in a primate facility in virginia, numerous macaques died, some with findings consistent with simian hemorrhagic fever (shf). the us army medical research institute of infectious diseases tested 10 animals and, from 3, isolated shf from tissues and serum; however, 5 other animals of the 10 tested were posi ...19902302743
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