| a complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis. | chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. here we describe a recombinant chikungunya virus vaccine comprising a non-replicating complex adenovirus vector encoding the structural polyprotein cassette of chikungunya virus. a single immunisation with this vaccine consistently induced ... | 2011 | 21320541 |