| [point mutations in dihydrofolate reductase and dihydropteroate synthase genes of plasmodium falciparum from three endemic malaria regions in colombia]. | plasmodium falciparum has the ability to counter the antiparasitic activity of sulphadoxine-pyrimethamine by progressively accumulating mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes. these mutations gradually increase the resistance of the parasite to these drugs and lead to therapeutic failure. | 2010 | 20890550 |