| [in vivo resistance of plasmodium falciparum to chloroquine in anjouan (comoros)]. | an in vivo study of p. falciparum sensitivity to chloroquine was conducted at anjouan island (république fédérale islamique des comores) from december 1990 to march 1991. the 27 patients included in the study were given chloroquine at a dose regimen of 25 mg/kg over 3 days and were followed up 7 days. six patients (22.2%) still harboured parasites up to day 7, thus showing a rii/riii level of resistance. this is likely related to an increased chloroquine consumption by the inhabitants of this is ... | 1993 | 8504263 |
| [evolutive visceral malaria and hyperimmune palustral splenomegaly: a difficult distinction]. | one case of hyperreactive malarial splenomegaly is reported for a comores island patient living in france and having thus lost his protective immunity. plasmodium falciparum was detected in a bone marrow aspiration, whereas peripheral venous blood samples were negative. a three-month treatment of sulfadoxine + pyrimethamine was effective with a complete regression of splenomegaly and biological disorders. | 1999 | 10214516 |
| [rapid detection of malaria and p. falciparum chemoresistant genotypes in mayotte, 2001]. | | 2002 | 12355993 |
| [a network rer rooted on in vitro readout assays of plasmodium falciparum sensitivity to chloroquine in the indian ocean region]. | chloroquine has been used as a first line drug to treat uncomplicated malaria cases during the last five decades in madagascar and in the comoros union. the four plasmodial species known to infect humans occur on madagascar island. chloroquine-resistant malaria cases, sometimes only suspected from presumptive malaria cases, have been reported in both countries. thus, to redefine a strategy and a policy to cure malaria, there is a need to get relevant and updated data. in december 1999, the madag ... | 2003 | 14530121 |
| measuring resistance to malaria. | | 2004 | 14971228 |
| susceptibility of plasmodium falciparum to the drugs used to treat severe malaria (quinine) and to prevent malaria (mefloquine, cycloguanil) in comoros union and madagascar. | to monitor the sensitivity of plasmodium falciparum to the drugs used to treat severe malaria and to prevent malaria in comoros and madagascar. | 2004 | 14971233 |
| short report: high prevalence of multidrug-resistant plasmodium falciparum malaria in the french territory of mayotte. | a drug-resistance survey was conducted in the french territory of mayotte in the comorian islands in the indian ocean where malaria is endemic. a high prevalence of resistant plasmodium falciparum parasites was observed, not only to chloroquine (88%) and pyrimethamine (99%), but more surprisingly to quinine (17%), mefloquine (9%), and amodiaquine (24%). this leaves few treatment alternatives other than artemisine-mefloquine combinations. however, despite notification to french health authorities ... | 2004 | 15211004 |
| efficacy of artemether-lumefantrine treatment in patients with acute uncomplicated falciparum malaria in mayotte, a french collectivity of the comoros archipelago. | mayotte is a french island located in the comoros archipelago in the indian ocean. due to the high level of resistance to chloroquine and sulfadoxine-pyrimethamine in this area, new therapeutic strategies are required. the aim was to assess and to document the efficacy of artemether-lumefantrine (al) combination in four oral dosages. the follow-up was carried out during 21 days to monitor the antimalarial drug efficacy in an open trial in april-may, 2002. results were obtained from 51 patients, ... | 2004 | 15490758 |
| plasmodium falciparum resistant to chloroquine and to pyrimethamine in comoros. | we report the outcome of chloroquine treatment and the prevalence of mutations at codon 86 of the pfmdr1 gene, at codon 76 of the pfcrt gene, and at codon 108 of the pfdhfr gene in clinical isolates of plasmodium falciparum collected from 30 children under 10 years of age living in the comoros union. this in vivo study was carried out in february and march 2001 in moroni. chloroquine treatment failed in 23 children (76.6%; 95% confidence interval: 57.7 to 90.1%). subsequent genotyping showed tha ... | 2004 | 15638145 |
| [chemosusceptibility analysis of plasmodium falciparum imported from comoros to marseilles, france in 2001-2003]. | the aim of this work was to study the chemosensitivity of plasmodium falciparum strains isolated from patients presenting with malaria after having returned from comoros islands in 2002-2003, and hospitalized at the north university hospital, in marseilles, france. | 2005 | 16310329 |
| [epidemiology and prevention of malaria in the southwestern islands of the indian ocean]. | malaria epidemiology differs greatly in the geographically close islands of the southwestern indian ocean. in madagascar and the comoros union malaria is still a major public health problem. in mayotte indigenous transmission resumed in 1995 and is currently high in some communities. in the mascarene islands (reunion and mauritius), indigenous transmission has been eradicated (reunion) or become rare (mauritius). the seychelles islands are malaria-free since local conditions are unfavorable for ... | 2006 | 16924826 |
| [malaria in mayotte: epidemiology, diagnostic, prevention and treatment]. | mayotte is a little french island, located in the indian ocean, between madagascar and mozambic. officially there is a population of 150000 inhabitants, but in fact, there are probably about 200000 people, largely due to numerous illegal immigrants, especially coming from anjouan the nearest comorian island. there is only one hospital, with 252 beds. the malaria incidence reaches about 3000 cases per year; and treatments until august 2001 were generally haphazard. this is changing with the use o ... | 2004 | 17304748 |
| [surveillance of falciparum malaria susceptibility to antimalarial drugs and policy change in the comoros]. | between may and june 2001, efficacy of chloroquine was assessed in 5 sentinel sites in the 3 comoro islands. among the 183 children, age range between 6 and 59 months, followed up for 14 days, clinical failure rates ranged between 31.2 and 73.1% and the total failure rate (clinical and parasitological) between 50 and 88.5%. failures were mainly early treatment failures. the ministry of health, during a consensus meeting decided to change the first line drug and to gather baseline information on ... | 2007 | 17402684 |
| efficacy of artesunate plus amodiaquine, artesunate plus sulfadoxine-pyrimethamine, and chloroquine plus sulfadoxine-pyrimethamine in patients with uncomplicated plasmodium falciparum in the comoros union. | health policy makers in comoros union have considered a policy change recommending combination treatment to control malaria. we evaluated the efficacy of three antimalarial drug combinations, taken orally, to enable the authorities to make an evidence-based choice. the study was carried out in patients of 2-70 years old in moroni, moheli and anjouan in 2003. we enrolled 168 patients with uncomplicated malaria from 1097 outpatients screened at the health centres. one hundred and fifty-eight patie ... | 2007 | 17568549 |
| antimalarial drug susceptibility and point mutations associated with drug resistance in 248 plasmodium falciparum isolates imported from comoros to marseille, france in 2004 2006. | a total of 248 plasmodium falciparum isolates were sampled in travelers with malaria who came to marseille, france from comoros to investigate in vitro activities of antimalarial drugs and molecular markers of drug resistance. of the 248 isolates, 126 were maintained in culture. of these, 53% were resistant to chloroquine, and 3% had reduced susceptibility to quinine, mefloquine, and atovaquone; 1% had reduced susceptibility to halofantrine and dihydroartemisinin; 7% had reduced susceptibility t ... | 2007 | 17827355 |
| drug-resistant malaria parasites introduced into madagascar from comoros islands. | to determine risk for drug-resistant malaria parasites entering madagascar from comoros islands, we screened travelers. for the 141 plasmodium falciparum isolates detected by real-time pcr, frequency of mutant alleles of genes associated with resistance to chloroquine and pyrimethamine was high. international-level antimalarial policy and a regional antimalarial forum are needed. | 2007 | 18217565 |
| first case of emergence of atovaquone-proguanil resistance in plasmodium falciparum during treatment in a traveler in comoros. | | 2008 | 18411319 |
| [is the antimalarial fight effective in mayotte?]. | | 2008 | 18786803 |
| [can the thick drop/smear examination for malaria be replaced by a rapid diagnostic test in first intention? the mayotte experience]. | malaria is a public health problem in the french island of mayotte (160,000 inhabitants) in the indian ocean. in the late 1990, resistance to chloroquine greatly increased, and so did the number of malaria cases, so that a new health policy had to be adopted. since 2001, the initial smear/thick drop examination, the results of which took too long to obtain, has systematically been replaced by a rapid diagnosis test (optimal it diamed) in all hospitals and public health centers. | 2009 | 18951743 |
| the malaria candidate vaccine liver stage antigen-3 is highly conserved in plasmodium falciparum isolates from diverse geographical areas. | a high level of genetic stability has been formerly identified in segments of the gene coding for the liver stage antigen-3 (lsa-3), a subunit vaccine candidate against plasmodium falciparum. the exploration of lsa-3 polymorphisms was extended to the whole sequence of this large antigen in 20 clinical isolates from four geographical areas; senegal, comoro islands, brazil and thailand. | 2009 | 19874576 |
| origins of the recent emergence of plasmodium falciparum pyrimethamine resistance alleles in madagascar. | the combination of sulfadoxine-pyrimethamine is recommended for use as intermittent preventive treatment of malaria during pregnancy and is deployed in africa. the emergence and the spread of resistant parasites are major threats to such an intervention. we have characterized the plasmodium falciparum dhfr (pfdhfr) haplotypes and flanking microsatellites in 322 p. falciparum isolates collected from the comoros islands and madagascar. one hundred fifty-six (48.4%) carried the wild-type pfdhfr all ... | 2010 | 20308388 |
| genetic structure of plasmodium falciparum and elimination of malaria, comoros archipelago. | the efficacy of malaria control and elimination on islands may depend on the intensity of new parasite inflow. on the comoros archipelago, where falciparum malaria remains a major public health problem because of spread of drug resistance and insufficient malaria control, recent interventions for malaria elimination were planned on moheli, 1 of 4 islands in the comoros archipelago. to assess the relevance of such a local strategy, we performed a population genetics analysis by using multilocus m ... | 2010 | 21029525 |