| enzyme-linked immunosorbent assay (elisa) for detection of antibodies to protein-reactive drugs and metabolites: criteria for identification of antibody activity. detection and hapten specificity of anti-dnp, anti-captopril and anti-sulphanilamidobenzoic acid. | certain hypersensitivity reactions to drugs are thought to depend on coupling of reactive species (the drug itself or a metabolite) to macromolecules, leading to the formation of hapten-carrier conjugates. in assays for the detection of antibodies directed against such reactive species the drug or metabolite must be used in conjugated rather than free form. we describe elisas for the detection of anti-dinitrophenyl (dnp), anti-captopril (cp) and anti-sulphanilamidobenzoic acid (saba) antibodies, ... | 1986 | 2420897 |