| pneumonic tularemia on martha's vineyard. | | 1979 | 481515 |
| early history (1936--1946) of nuclear medicine in thyroid studies at massachusetts general hospital. | | 1975 | 1102906 |
| fatal toxoplasmosis in domestic rabbits in the usa. | three rabbits from two sources died after an acute illness characterized by fever, lethargy and diarrhea in one rabbit and no clinical signs in two rabbits. the most striking lesion in all three rabbits was foci of necrosis of the spleen and liver associated with massive presence of multiplying toxoplasma gondii tachyzoites. the diagnosis was confirmed by specific staining with anti-t. gondii serum in an avidin-biotin complex immunohistochemical stain. | 1992 | 1466139 |
| clinical and laboratory findings in small companion animals with lead poisoning: 347 cases (1977-1986). | three hundred forty-seven cases of lead poisoning in small companion animals were reviewed. the yearly prevalence and overall incidence rates were examined for the 10 years before and after enactment of strict federal regulations pertaining to lead content in paint products. biographical data, clinical signs, and laboratory results were analyzed for the 6 types of affected animals (ie, dogs, cats, birds, rabbits, a chinchilla, and a raccoon). clinical and laboratory findings of these animals wer ... | 1991 | 1885338 |
| demographic data and treatment of small companion animals with lead poisoning: 347 cases (1977-1986). | three hundred forty-seven cases of lead poisoning in small animals, diagnosed after 1976, were reviewed. the types of treatments used and their outcomes were analyzed. changes in blood lead concentrations following various treatments, as well as the sources of lead exposure, were also reviewed. the geographic origins of the cases were traced, and demographic factors were studied to determine possible correlates that might explain the regional distribution of cases. | 1991 | 1909308 |
| a brugia species infecting rabbits in the northeastern united states. | brugia sp. microfilariae were observed in more than 60% of wild rabbits collected on nantucket island, massachusetts. the microfilariae measured 294-344 microns in length and had the characteristic subterminal and terminal nuclei observed in other brugia microfilariae. the microfilaria is similar to those described for brugia leporis in rabbits in louisiana. this may be the brugia species responsible for 21 documented cases of human infection in the northeastern united states. | 1991 | 1919934 |
| salivary antibody responses to oral and parenteral vaccines in children. | salivary iga antibody to poliovirus and tetanus toxoid was measured in whole salivas of 151 children between 2 and 48 months of age from north america and from scandinavia. children from urban and suburban populations in the greater boston, ma, area receive both oral poliovaccine and a parenteral injection with tetanus toxoid (tt), initially at approximately 2 months of age. children from göteborg, sweden, initially receive parenteral injections of tt at 2 months of age and parenteral injections ... | 1986 | 3958136 |
| genital herpes. some clinical and laboratory observations. | | 1974 | 4365597 |
| a case presentation of spontaneous thrombosis at last trimester of pregnancy. | | 1966 | 6011347 |
| potential use of shared antigens for immunization against gram-negative bacillary infections. | the demonstration of common antigens shared by all enterobacteriaceae has led to evaluation of the effects of immunization of animals and man with these antigens in protecting against bacterial infections and challenge with lps. both active and passive immunization with the re mutant of s. minnesota and the j5 mutant of e. coli afforded significant protection to mice and rabbits against lethal challenge with viable bacteria and heterologous lps. kdo appears to be the antigenic determinant respon ... | 1980 | 6163155 |
| diphtheria immunity in massachusetts--a study of three urban patient populations. | to determine the status of diphtheria immunity among our patients, we measured diphtheria antitoxin levels in three separate patient populations. the technique used was toxin neutralization in rabbit skin, which allowed us to evaluate the immune status of individual patients. we studied an emergency room population, a sampling of inpatients from an urban teaching hospital, and a group of older patients from a chronic care hospital. overall, approximately 80% of patients had adequate diphtheria a ... | 1984 | 6711585 |
| hypoimmunoglobulinemia d: frequency, family studies, and association with hla. | | 1981 | 7214744 |
| lead poisoning in small companion animals: an update (1987-1992). | eighty-five cases of lead poisoning in small companion animals were retrospectively studied. records from a lead toxicosis monitoring program at angell memorial animal hospital, boston ma were reviewed from 1987 through 1992. the number of cases of lead poisoning substantially declined from the previous 6 y. affected animals included 53 dogs, 20 birds, 8 cats, 3 rabbits and 1 iguana. ages ranged from 0.3-48 y, with a median age of 1.5 y. gastrointestinal and neurologic signs predominated. blood ... | 1994 | 8154098 |
| isolation of jamestown canyon and snowshoe hare viruses (california serogroup) from aedes mosquitoes in western massachusetts. | three isolates of jamestown canyon virus and one isolate of snowshoe hare virus (california serogroup) were obtained from adult aedes females collected in western massachusetts in 1982. jamestown canyon virus was isolated from aedes abserratus/punctor once, and from aedes intrudens twice. snowshoe hare virus was isolated from aedes stimulans group mosquitoes. la crosse encephalitis (lac) virus was not isolated from 1,552 adult aedes triseriatus, nor from 22,557 aedes triseriatus larvae. however, ... | 1993 | 8350066 |
| radioiodine and thyroid disease: the beginning. | in 1936, karl compton, then president of the massachusetts institute of technology (mit) and the thyroid group of the massachusetts general hospital (mgh), undertook a joint study that led to the production of small amounts of short-lived radioiodine (iodine 128, half-life, 25 min). the original intent was to use it for diagnosis and treatment of thyroid disease, but in order to explore the underlying physiology, their first work was performed in rabbits and published in 1938. it clearly showed ... | 1996 | 8829276 |
| diversity of babesia infecting deer ticks (ixodes dammini). | to determine whether the presence of nonpathogenic piroplasms may confound field estimates of risk of babesia microti infection, we identified sporozoites infecting the salivary glands of deer ticks (ixodes dammini) by parallel microscopy and polymerase chain reaction assays. piroplasms were evident in 14.4% of adult ticks from sites in the northcentral and northeastern united states. of these, 83.3% contained dna characteristic of ba. odocoilei. this cervid piroplasm was detected in all of the ... | 1998 | 9660456 |
| an outbreak of primary pneumonic tularemia on martha's vineyard. | in the summer of 2000, an outbreak of primary pneumonic tularemia occurred on martha's vineyard, massachusetts. the only previously reported outbreak of pneumonic tularemia in the united states also occurred on the island in 1978. | 2001 | 11757506 |
| tularemia revisited. | | 2001 | 11757513 |
| gregory pincus, father of the pill. | this paper presents the profiles of gregory pincus, popularly known as the "father of the pill". pincus was considered a brilliant scientist who developed an oral contraceptive in 1950. he had already achieved in vitro fertilization of rabbit eggs, foreshadowing later successes in assisted human reproduction that have enabled tens of thousands of couples to overcome infertility. his discovery, however, generated controversy, which cost him tenure at harvard, prompting his move to clark universi ... | 2000 | 12296230 |
| data complement anti-std activity of pro 2000 gel. contraceptives. | procept, cambridge, massachusetts, announced preclinical results demonstrating the contraceptive efficacy of its pro 2000 topical microbicide gel. in a program of late-breaking discoveries presented at the national conference on women and hiv, held in pasadena, california, procept scientists described the results of studies recently conducted with pro 2000. the in vitro results showed that pro 2000 was contraceptive when rabbits were dosed intravaginally with a gel containing a 4% concentratio ... | 1997 | 12320875 |
| preprandial inhibition of re-mating in ixodes ticks (acari: ixodidae). | questing female blacklegged ticks, ixodes scapularis, say in massachusetts rarely bear more than one endospermatophore in their reproductive tracts. we evaluated the cause of this nonrandom distribution by examining the stability of endospermatophore retention in females and the effect of prior insemination of females on the copulatory behavior of male ticks. endospermatophores were retained without degradation in unfed female ticks for >1 yr at 5 degrees c and for at least 4 mo at 21 degrees c. ... | 2002 | 12495182 |
| enzootic transmission of anaplasma bovis in nantucket cottontail rabbits. | serological studies of cottontail rabbits sampled from nantucket island, mass., have suggested exposure to at least two ehrlichiae. the agent of human granulocytic ehrlichiosis (anaplasma phagocytophilum) is intensely enzootic in rabbits there, but the identity of the other ehrlichial infection remains undescribed. we sampled rabbits over five transmission seasons and tested their blood and tissues for evidence of infection using pcr targeting an ehrlichia genus-wide 16s rdna target. sequence an ... | 2003 | 12904385 |
| enzootic transmission of babesia divergens among cottontail rabbits on nantucket island, massachusetts. | specific ticks seem to locally serve as vector for characteristic microbial assemblages (guilds) comprising spirochetes, piroplasms, ehrlichiae, and arboviruses. borrelia andersoni and anaplasma phagocytophilum are intensely transmitted between cottontail rabbits. to test the hypothesis that a piroplasm may also be maintained in rabbits, we sampled these hosts from nantucket island, massachusetts and tested their blood and tissues by a polymerase chain reaction for evidence of infection. surpris ... | 2003 | 14695079 |
| genotypic diversity of francisella tularensis infecting dermacentor variabilis ticks on martha's vineyard, massachusetts. | martha's vineyard, mass., has been the site of two outbreaks of tularemia (1978 and 2000). although most patients from both outbreaks presented with pneumonic disease and although aerosol transmission has been suggested, the bite of a dog tick and exposure to rabbits remain the only proven modes of transmission. the factors that precipitated the tularemia outbreaks or the proximal determinants of human risk remain undescribed. we sought to test the hypothesis that the ongoing outbreak is due to ... | 2004 | 15528681 |
| comparative infectivity of babesia divergens and a zoonotic babesia divergens-like parasite in cattle. | babesia divergens-like parasites identified in human babesiosis cases in missouri and kentucky and in eastern cottontail rabbits (sylvilagus floridanus) on nantucket island, massachusetts, share identical small subunit ribosomal rna gene sequences. this sequence is 99.8% identical to that of babesia divergens, suggesting that the u.s. parasite may be b. divergens, a causative agent of human and bovine babesiosis in europe. holstein-friesian calves were inoculated with cultured nantucket island b ... | 2005 | 16282295 |
| [progress on oecd chemicals programme (7)--siam 15 in boston, 2002]. | the 15th screening information data set (sids) initial assessment meeting (siam 15) was held in boston, usa. the initial assessment documents of twelve substances at siam 15 (cas numbers: 79-39-0, 88-60-8, 92-70-6, 102-76-1, 110-83-8, 135-19-3, 7647-01-0, 8007-18-9, 10043-52-4, 11070-44-3, 25321-09-9, 68186-90-3) were submitted by the japanese government with or without the international council of chemical associations (icca) and all of them on the human health effect parts were agreed at the m ... | 2005 | 16541752 |
| detection of babesia and anaplasma species in rabbits from texas and georgia, usa. | rabbits have been shown to harbor a suite of zoonotic organisms, including a babesia species, borrelia burgdorferi, and anaplasma phagocytophilum. in this study, we conducted a molecular survey for various tick-borne pathogens in three species of rabbits from texas and georgia. of 18 black-tailed jackrabbits (lepus californicus) tested from texas, six (28%) were polymerase chain reaction (pcr) positive for babesia, and nucleotide sequencing revealed two distinct species or strains. two jackrabbi ... | 2006 | 16584322 |
| raccoons and skunks as sentinels for enzootic tularemia. | we analyzed sera from diverse mammals of martha's vineyard, massachusetts, for evidence of francisella tularensis exposure. skunks and raccoons were frequently seroreactive, whereas white-footed mice, cottontail rabbits, deer, rats, and dogs were not. tularemia surveillance may be facilitated by focusing on skunks and raccoons. | 2006 | 16707067 |
| comparison of reactivity and epitope recognition between sera from american and italian patients with oral pemphigoid. | mucous membrane pemphigoid (mmp) (also known as cicatricial pemphigoid) is a rare autoimmune mucocutaneous blistering disease that affects mucous membranes derived from stratified squamous epithelium and the skin. a subset of mmp affects only the oral cavity and is referred to as the oral pemphigoid (op). mmp and op are characterized by subepithelial vesicles on histology and in vivo deposition of immunoglobulins and complement at the basement membrane zone (bmz) on immunopathology. previous stu ... | 2006 | 16792670 |
| phylogenetic and biologic evidence that babesia divergens is not endemic in the united states. | the causative agent of human babesiosis in a kentucky case, which was first identified as babesia divergens, is identical to a parasite of eastern cottontail rabbits on nantucket island, massachusetts based on piroplasm size, morphology, and ribosomal rna sequence analysis. studies showing differential infectivity for cattle, host erythrocyte specificity in vitro, parasite size and morphology in vitro, and ribosomal rna sequences clearly demonstrate that the parasite from the rabbit (conspecific ... | 2006 | 17135561 |
| quantifying the shelter rabbit population: an analysis of massachusetts and rhode island animal shelters. | scholarly work on the nonhuman animal shelter population has widely focused on cats and dogs. as a result, little is known about the population dynamics of domestic rabbits (oryctolagus cuniculus) in shelters. the records from 4 companion animal shelters in massachusetts and rhode island were analyzed to describe these dynamics. a majority of the rabbits at the 4 shelters were surrendered by their caregivers, were between 1 and 6 years old, and were unaltered at the time of intake. the most comm ... | 2012 | 23009621 |