| incidence and natural history of chemically defined varicella-zoster virus hepatitis in children and adolescents. | of 786 children and adolescents enrolled in a multicenter trial of acyclovir for chickenpox, 27 (3.4%) met the case definition of varicella-zoster virus (vzv) hepatitis (serum aspartate aminotransferase level > or = 100 u/l). the clinical and cutaneous manifestations of chickenpox in the 15 placebo recipients with this complication did not differ significantly from those in 45 matched controls (p > 0.05), indicating that liver involvement by vzv is not a consequence of more extensive disease. al ... | 1997 | 9112295 |