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assessment of the hazards of polybrominated biphenyls.during their peak use period, pbbs represented under 1% of the total sales of fire retardant chemicals, and very probably would have escaped intensive study if they had not been mixed accidentally with animal feed preparations. instead, international attention was drawn to pbbs by the state-supervised killing of over 35,000 cattle which had been contaminated with pbbs. interestingly, low doses of pbbs exert a broad spectrum of toxicological, pharmacological, and biochemical effects despite low a ...1978209999
parasites of black bears of the lake superior region.parasites collected from free-ranging black bears, ursus americanus pallas, 1780, from northeastern minnesota or northern michigan include the dog tick, dermacentor variabilis (say, 1821), the winter tick, d. albipictus (packard, 1869), a louse, trichodectes pinguis euarctidoes hopkins, 1954, an ascarid worm, baylisascaris transfuga (rudolphi, 1819), a filarial worm, dirofilaria ursi yamaguti, 1941, taeniid tapeworms, and unidentified fleas. the broad fish tapeworm, diphyllobothrium latum (linna ...19751142551
california serogroup virus infections in wisconsin domestic animals.a serologic survey and experimental virus transmission studies were done to assess the role of domestic animals as amplifier hosts of la crosse (lacv) and jamestown canyon (jcv) viruses. serum from 319 cows, 88 dogs, 122 equines, 47 swine, 10 goats, and 4 cats were tested for neutralizing antibody to lacv, jcv, trivittatus (tvtv), and snowshoe hare (sshv) viruses. antibody prevalences of lacv, tvtv, and sshv were less than 10% in all species. antibody to jcv was detected in all species except ca ...19883189702
epidemiologic aspects of blastomycosis, the enigmatic systemic mycosis.a growing body of epidemiologic information derives from the study of sporadic cases and seven epidemics of blastomycosis, although a complete epidemiologic description of the disease is impeded by the absence of a skin test and difficulty isolating the causative fungus, blastomyces dermatitidis, from nature. most cases occur sporadically in humans and dogs in a worldwide distribution. endemic areas in the united states include southeastern, southcentral, and midwestern states, particularly arka ...19863317597
immunoblot analysis of immunoglobulin g response to the lyme disease agent (borrelia burgdorferi) in experimentally and naturally exposed dogs.immunoblots were used to study the immunoglobulin g response to borrelia burgdorferi in experimentally and naturally exposed dogs. adsorption studies confirmed that the antibodies were specific for b. burgdorferi. experimentally exposed dogs were asymptomatic. naturally exposed dogs included both asymptomatic animals and animals showing signs compatible with lyme disease. naturally exposed dogs were from four geographic regions of the country. no differences were detected between immunoblot patt ...19883366860
canine diabetes mellitus has a seasonal incidence: implications relevant to human diabetes.a 3 year survey of practicing veterinarians in the state of wisconsin revealed a strong seasonal variation (peak incidence in january and february) for spontaneous canine diabetes mellitus (scdm) in pet dogs. this seasonal incidence was quite similar to that observed in insulin-dependent diabetes mellitus (iddm) in humans. scdm is etiologically heterogeneous, it has dissimilar etiologies as compared to iddm, and it is unlikely that viral infections play a causal role. for these reasons, it is co ...19873652619
canine antibody response to blastomyces dermatitidis wi-1 antigen.to assess whether dogs with blastomycosis produce antibodies against the wi-1 and a-antigens of blastomyces dermatitidis and whether the antibodies are useful in serodiagnosis.200010803652
epidemiologic features of pet evacuation failure in a rapid-onset disaster.to describe epidemiologic features of pet evacuation failure after a hazardous chemical spill in which residents had no warning and only a few hours notice to evacuate.200111417733
a survey of injuries at five greyhound racing tracks.the number of orthopaedic injuries sustained by racing greyhounds from five greyhound tracks in the state of wisconsin, usa, was obtained over a two-year period. calculated injury rates were analysed to predict the probability that a given competitor would have an injury based on track design, temperature, bodyweight, grade of race, race distance, race number, injury location on track and type of trauma. one track had a significantly higher injury rate than the others, and this track was constru ...199910516949
serological differences in two blastomyces dermatitidis isolates from different geographical regions of north america.yeast phase lysate antigens were prepared from two isolates (t-58 and erc-2) from different geographic locations. tennessee and wisconsin. these lysate were evaluated with respect to their ability to detect antibody in dogs infected with blastomycosis and rabbits immunized with the lysates by an enzyme linked immunosorbent assay (elisa). both the dog sera and rabbit sera assays demonstrated that there were serological differences in these two isolates, which implied that there was antigenic vari ...200211998876
antibiotic susceptibilities of anaplasma (ehrlichia) phagocytophilum strains from various geographic areas in the united states.we tested the antibiotic susceptibilities of eight strains of anaplasma phagocytophilum (the agent of human granulocytic ehrlichiosis) collected in various geographic areas of the united states, including minnesota, wisconsin, california, and new york. the results are homogeneous and show that doxycycline, rifampin, and levofloxacin are the most active antibiotics against these strains in vitro.200312499227
multistate outbreak of monkeypox--illinois, indiana, and wisconsin, 2003.cdc has received reports of patients with a febrile rash illness who had close contact with pet prairie dogs and other animals. the marshfield clinic, marshfield, wisconsin, identified a virus morphologically consistent with a poxvirus by electron microscopy of skin lesion tissue from a patient, lymph node tissue from the patient's pet prairie dog, and isolates of virus from culture of these tissues. additional laboratory testing at cdc indicated that the causative agent is a monkeypox virus, a ...200312803191
the in vitro isolation of blastomyces dermatitidis from a woodpile in north central wisconsin, usa.environmental isolations of the dimorphic fungus, blastomyces dermatitidis, the aetiologic agent of blastomycosis are rare, and have usually involved animal inoculation techniques. we report the in vitro isolation of b. dermatitidis from a woodpile in november 1997, from a private property in a highly endemic area of north central wisconsin, usa. the woodpile was 73 m from the wisconsin river and 5 m from a kennel which had housed nine dogs over the past 14 years, four of which had been diagnose ...199910421847
clinical findings in 40 dogs with hypersensitivity associated with administration of potentiated sulfonamides.the purpose of this study was to summarize the clinical findings in 40 dogs with systemic hypersensitivity reactions associated with the administration of potentiated sulfonamides. dogs ranged from 6 months to 14 years of age, with a mean of 5.7 +/- 3.2 years. spayed female dogs were overrepresented (24 of 40, or 60% of the dogs), as were samoyeds (3 of 40; 8%) and miniature schnauzers (5 of 40; 13%). mean dosages of potentiated sulfonamides were 47.0 +/- 14.9 mg/kg/d (range, 23.4-81.4 mg/kg/d). ...200314529130
pet therapy program. proposal for the us department of health and human services. 1996 secretary's award. 19979303917
canine lobular orbital adenoma: a report of 15 cases with distinctive features.to describe a unique orbital neoplasm in dogs, of lacrimal or salivary gland origin.200414738507
geographic, clinical, serologic, and molecular evidence of granulocytic ehrlichiosis, a likely zoonotic disease, in minnesota and wisconsin dogs.seventeen minnesota and wisconsin dogs with granulocytic ehrlichosis were studied. the diagnoses were made by finding ehrlichia morulae in peripheral blood neutrophils. eight dogs were studied retrospectively, and nine dogs were studied prospectively. the medical records of all dogs were reviewed. eighty-eight percent of the dogs were purebred and 76% were spayed females. the median age was 8 years. sixty-five percent of the cases were diagnosed in october and november. fever and lethargy were t ...19968748270
history of drugs for thrombotic disease. discovery, development, and directions for the future.the history of the antithrombotic agents--aspirin, heparin, warfarin, and the thrombolytics--is a rich and lively odyssey of serendipity, perseverance, vision, and conflict involving a number of striking personalities. the history of aspirin spans ages and continents from hippocrates' analgesic for women in labor to the rediscovery of the white willow bark by english country scholar reverend edward stone. bayer chemist felix hoffmann reinvented aspirin for his ailing father; suburban physician l ...19948281678
the epidemiology of blastomycosis in dogs: north central wisconsin, usa.the epidemiological features of 59 consecutive cases of blastomycosis in domestic dogs, from a single veterinary practice in eagle river, wisconsin over a 3-year period, were examined by owner interview. the control sample included: (i) all porcupine quill-injured dogs during this time period (outdoor exposed dogs); and (ii) every sixth dog receiving a rabies vaccination during the second year of study (representative of all dogs in the practice). the estimated mean annual incidence of blastomyc ...19957666297
west nile virus activity--united states, august 18-24, 2004.during august 18-24, a total of 154 cases of human west nile virus (wnv) illness were reported from 18 states (alabama, arizona, california, colorado, connecticut, florida, georgia, illinois, kentucky, minnesota, mississippi, missouri, nevada, new mexico, north carolina, south dakota, tennessee, and wisconsin).200415329654
west nile virus activity--united states, september 8-14, 2004.during september 8-14, a total of 195 cases of human west nile virus (wnv) illness were reported from 26 states (alabama, arizona, arkansas, california, colorado, florida, georgia, idaho, illinois, iowa, kansas, maryland, minnesota, missouri, nebraska, nevada, new mexico, new york, north dakota, oklahoma, oregon, pennsylvania, south dakota, tennessee, texas, and wisconsin).200415371969
west nile virus activity--united states, september 15-21, 2004.during september 15-21, a total of 218 cases of human west nile virus (wnv) illness were reported from 21 states (arizona, california, florida, illinois, indiana, kansas, maryland, michigan, minnesota, mississippi, missouri, nebraska, nevada, new mexico, north dakota, oklahoma, south dakota, texas, utah, wisconsin, and wyoming).200415385920
west nile virus activity--united states, september 22-28, 2004.during september 22-28, a total of 180 cases of human west nile virus (wnv) illness were reported in the district of columbia (dc) and 24 states (alabama, arizona, california, georgia, illinois, iowa, kansas, kentucky, louisiana, maryland, michigan, minnesota, mississippi, missouri, montana, nebraska, nevada, new mexico, ohio, pennsylvania, texas, utah, wisconsin, and wyoming).200415457147
monkeypox: a review of the history and emergence in the western hemisphere.a mysterious disease was reported on may 24, 2003, when the wisconsin division of public health (dph) received notice of a 3-year-old girl who had been hospitalized in central wisconsin with cellulites and fever after being bitten by a prairie dog on may 13. the laboratory isolated a gram-negative bacillus, raising concerns that it might be tularemia or plague; ultimately, it was identified as an acinetobacter species and was considered to be a contaminant. because no other such cases were repor ...200415494953
west nile virus activity--united states, october 13-19, 2004.during october 13-19, a total of 200 cases of human west nile virus (wnv) illness were reported from 20 states (arizona, arkansas, california, colorado, illinois, indiana, iowa, kansas, maryland, michigan, mississippi, missouri, nevada, new mexico, north carolina, oklahoma, pennsylvania, south dakota, wisconsin, and wyoming).200415499683
epidemiological studies on blastomycosis in the state of wisconsin.a study was made of 73 wisconsin cases of canine blastomycosis. each case was studied with respect to the life history of the animal. it was considered that a large percentage of the dogs were infected while in wisconsin, since 40 had never left the state, and it was highly probable that in a large percentage of the other 33 cases the disease was contracted while the dog resided in wisconsin. a study of the cases with respect to county of residence, birth and visitation revealed that there were ...19807434131
the incidence of facial injuries from dog bites.the incidence of hospital-treated facial injuries caused by dog bites was determined from a population-based study involving dane county, wisconsin, hospitals during 1978 and 1979. annual rates were shown to be 152 per 100,000 for ages 0 to 4 years, 128 per 100,000 for ages 5 to 9 years, and 62 per 100,000 for ages 10 to 14 years. severe facial injuries from dog bites were found almost exclusively in children younger than 10 years. if these rates apply to children in the us population, then an e ...19846727001
epidemic of pulmonary blastomycosis (namekagon fever) in wisconsin canoeists.epidemics of pulmonary blastomycosis have rarely been reported. the following epidemic occurred in a minnesota family and several of their acquaintances after a canoeing trip in northwestern wisconsin. the common exposure area was most likely a campsite, located along the upper reaches of the namekagon river. the namekagon river valley is a known endemic area of namekagon fever (blastomycosis) in dogs. approximately one month after returning home, five of the eight members of the group had posit ...19846488903
rabies surveillance in the united states during 2004.during 2004, 49 states and puerto rico reported 6,836 cases of rabies in nonhuman animals and 8 cases in human beings to the cdc, representing a 4.6% decrease from the 7,170 cases in nonhuman animals and 3 cases in human beings reported in 2003. approximately 92% of the cases were in wildlife, and 8% were in domestic animals (compared with 91% and 9%, respectively, in 2003). relative contributions by the major animal groups were as follows: 2,564 raccoons (37.5%), 1,856 skunks (27.1%), 1,361 bat ...200516379626
surgical excision of primary canine rectal tumors by an anal approach in twenty-three dogs.to describe an anal approach for excision of primary rectal tumors in dogs and to report outcome.200616756613
the isolation and identification of the anti-black tongue factor. 19744274128
brown spider envenomation.the venom from spiders of the genus loxosceles, the most famous being loxosceles recluse (the most brown recluse spider) can cause serious poisoning. these spiders inhabit the south and south central states from georgia through texas and north to southern wisconsin. they are commonly called violin spiders because of the violin-shaped marking on the dorsum of the cephalothorax. many dermonecrotic lesions are incorrectly diagnosed as brown recluse bites, as up to 50% of the diagnoses are in geogra ...200617265904
investigation of the spread of brucella canis via the u.s. interstate dog trade.the aim of this study was to illustrate and help address a growing need for regulatory or molecular tools to track and control the spread of canine brucellosis. our study objectives were to first characterize brucella canis outbreaks in wisconsin kennels in the context of the dog trade in the usa, and then to identify a molecular technique that may be useful for strain differentiation of b. canis isolates.200717331783
human rabies--indiana and california, 2006.rabies is a viral infection that causes acute, progressive encephalitis and is considered to be universally fatal. however, during 2004, an unvaccinated wisconsin patient received a new medical treatment and became the first documented survivor of rabies who had not received preexposure vaccination or postexposure prophylaxis (pep), suggesting the possibility of successful future interventions. this report describes two recent patients with rabies who were treated using therapy similar to that u ...200717443120
canine ocular histiocytic sarcoma.to describe and characterize histiocytic sarcoma (hs) first detected in the eyes of dogs using the large database at the comparative ocular pathology laboratory of wisconsin (coplow).200717445080
visceral larva migrans. a case from the la crosse area. 19854060754
epidemiologic study of canine blastomycosis in wisconsin.an epidemiologic study was designed to investigate the increasing number of cases of canine blastomycosis being reported in wisconsin. from january 1980 through july 1982, 200 cases of canine blastomycosis from 39 wisconsin counties were examined to assess epidemiologic and environmental aspects of this disease. based on a survey of 176 dog owners, principal disease characteristics for canine blastomycosis were anorexia, lethargy, shortness of breath, chronic cough, and weight loss. the greatest ...19873583882
ecologic niche modeling of blastomyces dermatitidis in wisconsin.blastomycosis is a potentially fatal mycosis that is acquired by inhaling infectious spores of blastomyces dermatitidis present in the environment. the ecology of this pathogen is poorly understood, in part because it has been extremely difficult to identify the niche(s) it occupies based on culture isolation of the organism from environmental samples.200818446224
natural exposure of wisconsin dogs to the lyme disease spirochete (borrelia burgdorferi).lyme disease, a tick-borne disease caused by borrelia burgdorferi, has been described recently in dogs. in a serologic survey of specimens obtained from march to september 1984, 53% of 380 dogs from two usda licensed vendors in wisconsin were positive for indirect immunofluorescent antibodies to b. burgdorferi at a serum dilution of 1:64 or greater. b. burgdorferi was cultured from the blood of 8/111 dogs. these findings suggest that exposure to this spirochete is common in endemic areas and tha ...19863523038
epidemiologic and immunologic evaluation of an outbreak of canine blastomycosis.five confirmed cases of canine blastomycosis occurred over the 10-month period of december 1983 to september 1984 in a south-eastern wisconsin colony of 30 dogs maintained for sled competition. contrary to other published reports of canine blastomycosis, the sex-specific attack rates were higher among females than males. four of the five confirmed cases and all four deaths occurred among young female dogs. differences in the age distribution and/or the micro-environment of the females may have c ...19883145971
an outbreak of human and canine blastomycosis.in the summer and fall of 1988, three humans and one dog in a lakeshore community in northern wisconsin were found to have blastomycosis on the basis of the results of cultures and histologic studies; the infection was also suspected in one human and four dogs on the basis of clinical data. serologic testing with use of enzyme immunoassay for antibody to the a antigen of blastomyces dermatitidis was performed for 77 additional human residents and visitors in the area an average of 9 months after ...19911962106
critical tests with pyrantel pamoate against internal parasites in dogs from wisconsin. 19751041522
agglutinins to brucella canis in stray dogs from certain counties in illinois and wisconsin.in a serologic and blood culture survey for brucella canis in 2,572 pound dogs from eight illinois and wisconsin counties, 173 (6.7%) were reactive in a presumptive slide test, 41 (1.5%) were reactive in a tube agglutination test, and 6 (0.2%) were positive in blood culture.1979500454
cluster of pulmonary blastomycosis in a rural community: evidence for multiple high-risk environmental foci following a sustained period of diminished precipitation.much of our understanding of the epidemiologic features of infection with blastomyces dermatitidis has come from cluster and outbreak investigations which have established the association of human disease with recreational pursuits and the presence of infectious microfoci in areas of moist soil with high organic content. this report describes the clustering of eight cases of pulmonary blastomycosis without an apparent common source exposure which occurred during a 90 day period in a 96 square mi ...200211998870
blastomycosis: more evidence for exposure near one's domicile.our previous publications on the epidemiology of blastomycosis suggested that the etiologic organism, blastomyces dermatitidis, may be acquired at home, however this view was challenged in an editorial.200111816782
human rabies---virginia, 2009.on october 28, 2009, cdc notified the virginia department of health (vdh) of suspected rabies in a virginia man aged 42 years. earlier that day, an infectious disease physician in virginia had contacted cdc requesting confirmatory diagnostic testing and reported initiating treatment with the milwaukee protocol after consultation with staff at the medical college of wisconsin. this report summarizes the patient's exposure history, clinical course, and treatment, and describes efforts to identify ...201020881935
rabies surveillance in the united states during 2010.during 2010, 48 states and puerto rico reported 6,154 rabid animals and 2 human rabies cases to the cdc, representing an 8% decrease from the 6,690 rabid animals and 4 human cases reported in 2009. hawaii and mississippi did not report any laboratory-confirmed rabid animals during 2010. approximately 92% of reported rabid animals were wildlife. relative contributions by the major animal groups were as follows: 2,246 raccoons (36.5%), 1,448 skunks (23.5%), 1,430 bats (23.2%), 429 foxes (6.9%), 30 ...201121916759
canine surveillance system for lyme borreliosis in wisconsin and northern illinois: geographic distribution and risk factor analysis.a seroprevalence survey for borrelia burgdorferi was conducted among the healthy canine pet population in selected counties of wisconsin and northern illinois to determine the distribution of lyme disease and associated risk factors. information obtained for each dog included place of residence, lyme disease vaccination status, history of travel and tick exposure, signalment, and medical history. serum samples were screened by enzyme-linked immunosorbent assay and confirmed by an immunoblot proc ...200111716112
commercial dry dog food in the north central united states is not contaminated by dermatophagoides house dust mites.contamination of home-stored cereal grain food products with dermatophagoides spp. house dust mites (hdm) was reported recently, along with anaphylaxis after consumption of these foods by dust mite-allergic people. we hypothesized that commercial dry dog food could become similarly contaminated, particularly if stored improperly, and could eventually contribute to allergic signs in dogs. newly purchased bags of dry dog food (n = 30), from a variety of sources and manufacturers, and client sample ...200111493401
a study of the morphology of canine eyes enucleated or eviscerated due to complications following phacoemulsification.this study was undertaken to describe the histopathologic abnormalities observed in canine eyes enucleated or eviscerated due to complications following phacoemulsification; to correlate these findings with the clinical abnormalities reported, and to suggest, if apparent, likely causes and effects of these abnormalities. sixty-six canine globes or evisceration samples received for histopathologic interpretation over a 10-year period (1990-2000) were studied. all globes and evisceration samples w ...200312950653
the detection of monkeypox in humans in the western hemisphere.during may and june 2003, an outbreak of febrile illness with vesiculopustular eruptions occurred among persons in the midwestern united states who had had contact with ill pet prairie dogs obtained through a common distributor. zoonotic transmission of a bacterial or viral pathogen was suspected.200414736926
efficacy and toxicity of paclitaxel (taxol) for the treatment of canine malignant tumors.paclitaxel (taxol) was administered to 25 dogs with histologically confirmed malignant tumors at a dosage of 165 mg/m2 i.v. over 3-6 hours every 3 weeks. dogs received premedication with antihistimines and corticosteroids to reduce hypersensitivity reactions. however, 64% of the dogs still experienced allergic reactions. six dogs (24%) had grade 3 or 4 neutropenia, 6 dogs (24%) required hospitalization and 3 dogs (12%) died of sepsis. five dogs (20%) had a partial response (osteosarcoma [2 dogs] ...200415058774
animal bites and rabies: physicians and veterinarians must work together. 19968992799
incidence of dog bites in milwaukee, wis.dogs are everywhere. the incidence of and injuries caused by dog bites have grown to such epidemic proportions in certain parts of the united states that they are now considered a major public health concern. playful rover is no longer a harmless pet. uncontrolled, he now can be considered a public nuisance. in this study, we evaluated the epidemiology of dog bites recorded in milwaukee, for calendar years 1989-1991. this assessment included anatomical location of bites, victims' ages, behaviora ...19968992798
monkeypox in the united states: an occupational health look at the first cases.between may 15 and june 20, 2003, 71 suspected cases of monkeypox were investigated and 37 individuals in the united states developed laboratory confirmed monkeypox. these were the first cases of human monkeypox ever documented in the united states or in the western hemisphere. the disease was transmitted from small animals imported from africa to other animals, including prairie dogs sold as pets throughout the u.s. midwest. direct contact with the infected animals was the method of infection, ...200415119816
toxicity, dosage, and efficacy of vinorelbine (navelbine) in dogs with spontaneous neoplasia.the purpose of this study was to evaluate short-term adverse effects and determine a safe dosage for vinorelbine (navelbine)--a new semisynthetic vinca alkaloid--in dogs with malignant tumors. nineteen dogs were treated with vinorelbine as a 5-minute iv infusion every 7 days at starting dosages ranging from 10 to 20 mg/m2. the median number of treatments per dog was 7 (range, 1-11). the maximum tolerated dosage varied between 15 and 18 mg/m2, and a starting dosage of 15 mg/m2 is recommended. neu ...200415320594
contrast harmonic ultrasound of spontaneous liver nodules in 32 dogs.thirty-two dogs with spontaneous hepatic nodules were given intravenous ultrasound contrast medium (definity or sonovue) and imaged with contrast harmonic software on a conventional ultrasound machine system. digital video images were initially reviewed to describe the perfusion pattern of malignant nodules. the images were reviewed again to test this pattern against all individual nodules. subjectively, there was improved conspicuity of malignant nodules after contrast enhancement compared with ...200415605847
geographic information system analysis of blastomycosis in northern wisconsin, usa: waterways and soil.geographic information systems (gis) are powerful tools for investigating the ecogeography of environmentally acquired infections. gis technology was used to geocode and map cases of blastomycosis, by household, of human and dog residents of vilas county, wisconsin, usa. human case households (n = 136) were from a comprehensive street address registry 1979--2001; human controls were 200 random-number selected households from 2001 county tax records. dog cases (n = 116) were from a consecutive st ...200515832555
cutaneous larva migrans; recent experience in the la crossa area. 19807368763
variation in wisconsin mastitis test scores of bucket milk samples and relationship to bacterial infections.sources of variation in the wisconsin mastitis test were studied in 4739 bucket milk samples from 111 cows in one herd during 103 days. quarters of cows were classified infected or uninfected through bacteriologic assays of quarter milk samples. quarters were uninfected in 70.4% of the cow-quarter-days and infected with staphylococcus aureus and streptococcus agalactiae in 1.4 and .9% of the quarter samples. scores of all cow-days averaged 8.5. wisconsin mastitis test scores of cow-days having n ...19817264013
canine goniodysgenesis-related glaucoma: a morphologic review of 100 cases looking at inflammation and pigment dispersion.to investigate the role of pigment dispersion and inflammation in the pathogenesis of goniodysgenesis-related glaucoma (gdrg).200516008705
canine conjunctival hemangioma and hemangiosarcoma: a retrospective evaluation of 108 cases (1989-2004).canine conjunctival tumors of vascular endothelial origin are common, although under-reported. the purpose of this study was to evaluate the epidemiology of and potential risk factors for these tumors. this study evaluated 108 cases (70 hemangiomas, 38 hemangiosarcomas) from 8300 canine submissions between 1989 and 2004. signalment, location, pigmentation, size, duration, diagnosis, margins, ancillary therapy, and geographic location were recorded. follow-up information was available for 49 case ...200616771756
occupational risks during a monkeypox outbreak, wisconsin, 2003.we determined factors associated with occupational transmission in wisconsin during the 2003 outbreak of prairie dog--associated monkeypox virus infections. our investigation included active contact surveillance, exposure-related interviews, and a veterinary facility cohort study. we identified 19 confirmed, 5 probable, and 3 suspected cases. rash, headache, sweats, and fever were reported by > 80% of patients. occupationally transmitted infections occurred in 12 veterinary staff, 2 pet store em ...200717953084
distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases.canine optic nerve hypoplasia (onh) and aplasia (ona) are significant neuro-ophthalmologic disorders that have been reported in several species. the purpose of this study was to describe the distinctive histopathologic features of onh and ona in canine patients identified from a collection of 20 000 ocular submissions at the comparative ocular pathology laboratory of wisconsin from 1989 to 2006. the following information about onh and ona cases was collected: signalment, and clinical and gross f ...200818190348
four-fraction radiation therapy for macroscopic soft tissue sarcomas in 16 dogs.a retrospective study of 16 dogs with macroscopic soft tissue sarcomas was performed to evaluate response to a four-fraction radiotherapy protocol (prescribed dose of 32 gy). radiation was well tolerated with minimal side effects. the overall response rate was 50%, with seven partial responses and one complete response. the median time to progression was 155 days, and the median survival time was 309 days. coarsely fractionated radiation therapy may be a reasonable palliative option for dogs wit ...200818451067
prevention of cold ischemia/rewarming-induced erk 1/2, p38 kinase and ho-1 activation by trophic factor supplementation of uw solution.we have previously shown that trophic factor supplementation (tfs) of university of wisconsin (uw) solution reduced early apoptotic changes in vascular endothelial cells. here, we examine the effect of tfs on cell signaling pathways related to cell growth, differentiation, and apoptosis after cold ischemic storage. in this study, the effect of tfs on the phosphorylation of signaling molecules erk (extracellular regulated-signaling kinase) 1/2 and p38 mapk (mitogen activated protein kinases) and ...200818538757
immunization of black-tailed prairie dog against plague through consumption of vaccine-laden baits.prairie dogs (cynomys spp.) are highly susceptible to yersinia pestis and, along with other wild rodents, are significant reservoirs of plague for other wildlife and humans in the western united states. a recombinant raccoon poxvirus, expressing the f1 antigen of y. pestis, was incorporated into a palatable bait and offered to three groups (n = 18, 19, and 20) of black-tailed prairie dogs (cynomys ludovicianus) for voluntary consumption, either one, two, or three times, at roughly 3-wk intervals ...200818957649
effects of season and weather on blastomycosis in dogs: northern wisconsin, usa.dogs and humans acquire blastomyces dermatitidis infections from the same incompletely defined habitat. studies of blastomycosis cases have not consistently demonstrated seasonality or significant antecedent climate effects. to determine the distribution of disease by season, we studied over 18 years 219 dogs with blastomycosis from a single veterinary practice in northern wisconsin. the 202 vilas county dog addresses were compared to 200 random-number selected addresses from the practice regist ...201120491530
angiofibroma of the nasal cavity in 13 dogs.this case series describes a rare entity, nasal angiofibroma, in 13 dogs that were presented to the university of wisconsin, school of veterinary medicine from 1988 to 2000. all dogs in this case series presented with clinical signs and radiographic changes that were strongly suggestive of a locally invasive neoplasm. however, histopathology completed on transnostral core biopsy samples revealed benign appearing vascular proliferation with secondary lymphosuppurative inflammation was established ...201122077412
Peri-operative Morbidity Associated with Ovariohysterectomy Performed as Part of a Third-Year Veterinary Surgical-Training Program.The present study describes the morbidity associated with ovariohysterectomy (OVH) when performed by third-year veterinary students as part of a surgical-training program. Data recorded from medical records included signalment, concurrent illness(es), surgical procedure(s), anesthesia and surgery time, anesthetic and surgical complications, and semester performed. The students' surgical training before the OVH included 39 lecture and 26 laboratory hours. In the present study, 513 animals (206 do ...201122130417
gray wolf exposure to emerging vector-borne diseases in wisconsin with comparison to domestic dogs and humans.world-wide concern over emerging vector-borne diseases has increased in recent years for both animal and human health. in the united sates, concern about vector-borne diseases in canines has focused on lyme disease, anaplasmosis, ehrlichiosis, and heartworm which infect domestic and wild canids. of these diseases, lyme and anaplasmosis are also frequently diagnosed in humans. gray wolves (canis lupus) recolonized wisconsin in the 1970s, and we evaluated their temporal and geographic patterns of ...201627898670
cutaneous pythiosis in two dogs from wisconsin, usa.pythium insidiosum is an oomycete that causes cutaneous lesions or infiltrative gastrointestinal disease in dogs, cats, humans, horses and other mammals, primarily in tropical and subtropical climates.201424372864
anaplasma phagocytophilum infection in dogs: 34 cases (2000-2007).objective- to determine demographic characteristics of dogs from the upper midwest infected with anaplasma phagocytophilum and identify clinical and clinicopathologic abnormalities and response to treatment. design- retrospective case series and owner telephone survey. animals- 34 dogs with granulocytic anaplasmosis. procedures- records were reviewed for information on signalment, history, physical examination findings, clinicopathologic and serologic findings, and treatment. owners were contact ...200919527130
attempted isolation of blastomyces dermatitidis from the nares of dogs: northern wisconsin, usa.the nasal cavities of domestic animals may concentrate and allow isolation of environmentally acquired fungal pathogens. we obtained two swabs each from the nares of 110 asymptomatic, physically normal dogs from a veterinary practice in eagle river, wi, usa, an area highly endemic for blastomycosis. four of the tested dogs had past histories of blastomycosis. samples were placed on yeast extract phosphate (smith's) media at 20 degrees c but growth of blastomyces dermatitidis was not observed on ...200919888812
identification and phylogenetic analysis of dirofilaria ursi (nematoda: filarioidea) from wisconsin black bears (ursus americanus) and its wolbachia endosymbiont.dirofilaria ursi is a filarial nematode of american black bears (ursus americanus pallas, 1780) that is vectored by black flies (simuliidae) in many parts of the united states. in northwestern wisconsin, the prevalence of microfilaremic bears during the fall hunting season was 21% (n = 47). unsheathed blood microfilariae from wisconsin bears possess characters consistent with the original description of d. ursi, as do adult worms observed histologically and grossly. immunohistochemistry was used ...201019916630
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