Publications

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[number of animals used in experiments in 1990--results of a survey--jalas working group for laboratory animal data bank, tokyo and life science research information section, the institute of physical and chemical research, saitama].a survey on the number of animals used in experiments including bioassay, diagnosis, education and preparation of biological agents such as vaccine between april 1990 and march 1991 was conducted. out of 849 universities, institutes, testing laboratories and companies, 607 replies were received. the distribution of the number of animals is shown in the following tables. [tables; see text]19921740161
canine and feline lymphoid and myeloid tumors encountered in tokyo. 19883210493
comparison of ehrlichia muris strains isolated from wild mice and ticks and serologic survey of humans and animals with e. muris as antigen.in metropolitan tokyo, the ehrlichia muris seropositivity rate of 24 wild mice was 63% in hinohara village, but in the surrounding areas, it was 0 to 5%. this finding suggests that the reservoir of e. muris is focal. among the 15 seropositive mice, ehrlichiae were isolated from 9 apodemus speciosus mice and 1 a. argenteus mouse, respectively. five ehrlichial isolates were obtained from 10 ticks (haemaphysalis flava) collected in asuke town, aichi prefecture, where the e. muris type strain had be ...199910074536
hypoxic and ischemic disorders of infants and children. lecture for 38th meeting of japanese society of child neurology, tokyo, japan, july 1996.hypoxia-ischemia damages selected regions of the immature at different ages. prior to 32 weeks gestation the periventricular white matter is selectively vulnerable but in the last trimester the basal ganglia become especially vulnerable to injury. hypoxia-ischemia causes injury by activating a series of biochemical events that unfolds over a period of hours to days following the initial insult and we are investigating the ways in which age modifies these events. the cascade includes release of g ...19979187471
prognosis for canine malignant mammary tumors based on tnm and histologic classification.the 2-year prognosis of malignant mammary tumors seen in 175 bitches in the tokyo metropolitan area was assessed based on their tnm clinical staging and histological classification. the larger the tumor size became (t category), the poorer was the clinical prognosis. the 2-year survival rates of the animals with regional lymph node metastasis of tumor cells (n1, n2 category) and/or distant metastasis (m1 category) were markedly lower than those of the animals without such involvement. as the gra ...19968959655
the dawn of excitatory amino acid research in japan. the pioneering work by professor takashi hayashi.the excitatory action of glutamate and aspartate upon direct application to the motor cortex of dogs was first reported in 1952 by takashi hayashi, keio university school of medicine, tokyo. although this investigation had been performed in the early 1940s during the second world war, the publication in english was delayed in the difficult post-war circumstances. when sodium glutamate was applied to the exposed motor cortex in 1-2 mol (not mmol) concentrations, the convulsions of a clonic type w ...19968885280
epidemiological observations on recent outbreaks of canine distemper in tokyo area.recent outbreaks of canine distemper virus (cdv) infection in tokyo area were investigated on the basis of clinical features and serological test. the affected dogs were clinically classified into two groups; dog with respiratory and gastrointestinal signs associated with central nervous system (cns) signs, and those with cns signs alone. of 62 dogs examined, 34 belonged to the former and 28 to the latter. in immunoperoxidase assay, anti-onderstepoort strain of cdv serum reacted at a low level a ...19968811624
pathology and epidemiology of canine distemper in raccoon dogs (nyctereutes procyonoides).from september to december 1991, a large number of free-ranging raccoon dogs (nyctereutes procyonoides) died from a highly contagious disease in the vicinity of tokyo. eighteen seriously ill or dead animals were submitted for necropsy. the pathological findings resembled those in a masked palm civet (paguma larvata) found infected with canine distemper virus (cdv) in the same area in late august 1991. the most striking features were pneumonia and gastroenteritis. microscopical lesions consisted ...19938366205
[idiopathic neurologic diseases in dogs and cats in japan from the viewpoint of animal models of human disease (author's transl)].this study was intended to demonstrate the neurological characteristics of idiopathic neurologic diseases of dogs and cats as a material for evaluating them as animal models for human diseases. a hundred and nineteen animals selected for this study from among outpatients with various neurological disorders presented to the veterinary hospital of university of tokyo were studied mainly by the neurological examination with assistant methods of electroencephalography and electromyography. hydroceph ...19817318928
oxychlordane, trans-nonachlor and cis-nonachlor residues in adipose tissues of dogs and cats collected in the tokyo area. 19817284639
a survey of canine dirofilaria invasion in a suburb of tokyo (nerima ward). 19817265821
distribution of environmental pollutants in pet animals. vi. heavy metals in hair of house-dogs. 19817225623
detection of brucella canis infection in dogs from tokyo area. 19744477624
an investigation of canine leptospiral antibodies in tokyo and yokohama. comparison of canine positive rates between rapid microscopic agglutination test and schüffner-mochtar test. 19744468963
kennel cough complex: confirmation and analysis of the outbreak in japan. 19882845177
epidemiological studies on the expectation of life for cats computed from animal cemetery records.based on the chiang's method, the life table for cats was constructed from the death data of 3936 cats. they died in the kanto area and were buried in an animal cemetery in tokyo from june 1981 through may 1982. this life table seems to be the first one for domestic pet cats. the expectation of life for cats was 4.2 years at age 0, 5.0 years at age 1, 5.4 years at age 4, 5.3 years at age 5, 3.5 years at age 10, and 2.2 years at age 15. the maximum age at death was 22 years. from age 0 to age 5, ...19892607740
a survey of brucella canis infection in dogs from tokyo area. 1978642226
[phylogenetic analysis of rabies viruses isolated from animals in tokyo in the 1950s].molecular epidemiological analysis of 96 rabies viruses isolated from animals in tokyo in the 1950s involves japanese fixed virus, komatsugawa, takamen, and nishigahara strains. strains isolated in tokyo were divided into tokyo 1 and tokyo 2, and grouped into a worldwide distribution cluster differing from takamen and nishigahara. tokyo 1 was grouped into the same cluster as viruses isolated from united states west coast dogs in the 1930s and 1940s. tokyo 2 was grouped into the same cluster as t ...201121706842
age-specific plasma biochemistry reference ranges in <1 year old dogs in japan.the purpose of this study was to investigate and propose possible reference intervals of plasma biochemical analytes in young dogs (<12 months old) in japan, using 896 canine plasma samples, collected from an array of veterinary clinics throughout the greater tokyo metropolis area in japan. the following biochemical parameters were assessed: albumin (alb), alanine aminotransferase (alt), alkaline phosphatase (alp), amylase, aspartate aminotransferase (ast), blood urea nitrogen (bun), creatinine ...201121331514
autoantibodies against glial fibrillary acidic protein in canine sera. 200818453380
interdigital involvement in a case of primary cutaneous canine histoplasmosis in japan.a 5-year-old male siberian husky bred outdoor in tokyo had a swollen paw with interdigital granulomatous lesions in the left hindlimb. the dog had no apparent pulmonary or gastrointestinal involvement. histopathological analysis of the skin lesions demonstrated yeast-like organisms predominantly within macrophages. sequence analysis of fungal ribosome rna gene isolated from a paraffin sample revealed a 100% homology with the teleomorph of histoplasma capsulatum. the present case may support the ...200516268961
epidemiological survey of babesia gibsoni infection in dogs in eastern japan.to determine the distribution of babesia gibsoni infection in dogs in the eastern part of japan, an epidemiological survey of dogs suspected of having b. gibsoni infection was attempted using the polymerase chain reaction (pcr) and enzyme-linked immunosorbent assay (elisa). thirty-five of 115 such dogs (30.4%) were positive by pcr and/or elisa. the 35 positive dogs consisted of 28 tosa dogs, 4 american pit bull terriers, and 3 mongrel dogs in aomori, fukushima, ibaraki, gunma, chiba, tokyo, kana ...200515942130
prevalence of dirofilarial infection in raccoon dogs in japan.the raccoon dog (nyctereutes procyonoides viverrinus) is known to acquire canine heartworm (dirofilaria immitis) infection. we surveyed the prevalence of heartworm infection in free-ranging raccoon dogs in the nishi-tama (tokyo) and kanagawa areas of japan. a total of 75 raccoon dog carcasses, including 29 animals from the nishi-tama area and 46 from the kanagawa area, were necropsied between 1992 and 1993. eight out of 75 raccoon dogs were found to be infected (overall 10.7%). the prevalence of ...200011426580
histopathological features of canine distemper recently observed in japan.eleven dogs with canine distemper (cd) from the chubu region of japan and the tokyo area were examined. clinically, respiratory and neurological signs were present in all animals. histopathologically, all showed characteristic cd lesions of bronchopneumonia and demyelinating encephalitis. however, some differences in gastrointestinal abnormalities were observed. three out of four dogs from the chubu region had severe diarrhoea and gastroenteritis, associated with numerous eosinophilic inclusion ...19979179753
hair mercury concentrations in cats and dogs in central japan.hair mercury concentrations were measured in 41 cats and 34 dogs living in kanagawa, saitama and tokyo prefectures. total mercury concentrations measured by atomic absorption spectrometry were significantly higher (p < 0.01) in cats [7.40 parts per million (ppm) in males and 7.45 ppm in females] than in dogs (0.99 ppm in males and 0.66 ppm in females). mercury in cat hair was correlated with age (p < 0.01) and higher in cats fed with foods prepared by the owners than in those fed with commercial ...19958920117
influence of ovariectomy at the time of mastectomy on the prognosis for canine malignant mammary tumours.the two-year prognosis for malignant mammary tumours seen in 175 bitches in the tokyo metropolitan area was assessed based on the extent of mastectomy and on whether an ovariectomy was carried out at the time of mastectomy. the prognosis for the bitches was not influenced by the excision size of the affected mammary glands. ovariectomy had no effect on the two-year survival rate of the dogs that underwent the tumour excision. there was no significant difference in the two-year survival rate betw ...19968912239
possible association of glaucoma with pectinate ligament dysplasia and narrowing of the iridocorneal angle in shiba inu dogs in japan.the purpose of the study was to describe the shape of the pectinate ligament (pl) and to estimate the width of the iridocorneal angle (ica) in glaucomatous and non-glaucomatous eye of shiba inu dogs in japan. one hundred fourteen shiba inu dogs were presented to the veterinary medical center at the university of tokyo between june 1998 and june 2003. among these, 46 dogs had glaucoma; the remaining 68 dogs were presented for routine vaccinations or heartworm testing and were used as a control po ...200616497230
experimental studies on toxascaris leonina. i. incidence of t. leonina among dogs and cats in japan. 19675624719
a survey of plesiomonas shigelloides from aquatic environments, domestic animals, pets and humans.we conducted a survey during the period from 1974 to 1976, to determine the distribution of plesiomonas shigelloides in human faeces, the intestinal contents of cattle, swine, poultry, dogs, cats, fresh water fish, and river water and sludge from wet riverbeds in the vicinity of tokyo. isolation of the organisms was performed by using salmonella-shigella (ss) agar and deoxycholate-hydrogensulphide-lactose (dhl) agar plates. p. shigelloides was isolated from 3 (0.0078%) of 38454 healthy tokyoites ...19807358962
a retrospective histopathological survey on canine and feline liver diseases at the university of tokyo between 2006 and 2012.to determine the incidence of hepatic diseases in dogs and cats in japan, a retrospective study was performed using data of 463 canine and 71 feline liver biopsies at the veterinary medical center of the university of tokyo. the most common canine hepatic disease was microvascular dysplasia (mvd) and occupied 29.4% of all diagnoses. this terminology might contain "real" mvd and primary portal vein hypoplasia, because these two conditions were difficult to be clearly distinguished histopathologic ...201424717415
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