Publications

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spotted fever in hong kong.a previously healthy 7-year-old hong kong-born caucasian child developed sudden onset fever, followed by a generalized rash and systemic symptoms of rigor and prostration, mucous membrane involvement (conjunctivitis) and arthralgia. he lives in a rural area of hong kong and has been in contact with various domestic animals--rodents, dogs and cows. chloramphenicol 50 mg/kg/day was given on day 4 with rapid response. subsequent weil-felix test and specific serology suggested the diagnosis of ricke ...19921280039
human rabies in hong kong: a case review.five human rabies cases were reported in hong kong between 1980 and 1984. a review of their clinical data showed only 2 had a definite history of dog bite, while 3 were residents in the infected area. the human outbreak concurred with the epizootic of canine rabies. however, only two cases were diagnosed ante-mortem. two cases were not even suspected as rabies until proven by post mortem pathological examination. three of five cases presented as non-specific encephalitis. all the patients died, ...19873446009
a pragmatic approach to timely disease surveillance in the emergency department.computerised emergency department (ed) logs have been in use for more than 20 years. despite this, public health authorities have failed to fully utilise this important surveillance tool.200312954684
chrysomya bezziana in pet dogs in hong kong: a potential threat to australia.the old world screwworm fly (chrysomya bezziana) has recently been causing aggressive myiasis in pet dogs in hong kong, and the agriculture, fisheries and conservation department of hong kong has confirmed the presence of chrysomya bezziana in the territory. this report describes screwworm infestation in pet dogs presented for treatment at our clinic in the past year. screwworm fly larvae were found in typically punched out round wounds or embedded in exposed or neglected wounds. infested wounds ...200315080442
low rate of methicillin-resistant coagulase-positive staphylococcal colonization of veterinary personnel in hong kong.elevated rates of methicillin-resistant staphylococcus aureus (mrsa) carriage have been reported in veterinary personnel, suggesting an occupational colonization risk. hong kong veterinary personnel (n = 150) were sampled for coagulase-positive staphylococci (cps) nasal colonization. risk factors for colonization were assessed by questionnaire. isolates were identified and antibiotic susceptibility determined. all cps isolates were investigated for meca carriage, sccmec type and pvl genes. two s ...201119968853
extensive dissemination of ctx-m-producing escherichia coli with multidrug resistance to 'critically important' antibiotics among food animals in hong kong, 2008-10.to assess the occurrence of faecal carriage of escherichia coli with resistance to 'critically important' antibiotics in various animals.201121393133
comparative evaluation of a point-of-care immunochromatographic test snap 4dx with molecular detection tests for vector-borne canine pathogens in hong kong.abstract there are no comprehensive studies on the performance of commonly used point-of-care diagnostic enzyme immunoassay for common arthropod-borne canine pathogens. a comparative evaluation of an immunochromatographic test for these infections with a comprehensive polymerase chain reaction (pcr) test panel was performed on 100 pet dogs and 100 stray dogs without obvious clinical symptoms. of the 162 positive test results from both immunochromatographic test and pcr, there was 85.2% concordan ...201121612526
issues associated with dog bite injuries in children and adolescents assessed at the emergency department.the aim of this study was to determine the pattern of dog bites seen at the emergency department of a university hospital. the information will be used to plan prevention and enhance management strategies.200717666924
the skin prick test results of 977 patients suffering from chronic rhinitis in hong kong.to evaluate the prevalence of aetiological allergens identifiable by skin prick test alone in patients suffering from chronic rhinitis in hong kong, and also compare the clinical history and symptoms of skin prick test-positive versus skin prick test-negative patients.200717406040
retrospective study of old world screw-worm fly (chrysomya bezziana) myiasis in 59 dogs in hong kong over a one year period. 200415359961
wet markets--a continuing source of severe acute respiratory syndrome and influenza?context: live-animal markets (wet markets) provide a source of vertebrate and invertebrate animals for customers in tropical and subtropical regions of the world. wet markets sell live poultry, fish, reptiles, and mammals of every kind. live-poultry markets (mostly chicken, pigeon, quail, ducks, geese, and a wide range of exotic wild-caught and farm-raised fowl) are usually separated from markets selling fish or red-meat animals, but the stalls can be near each other with no physical separation. ...200414738798
a polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in chinese children.interleukin (il)-13 is an important cytokine secreted from type 2 helper t lymphocytes. it is essential for modulating ige synthesis by human b cells. previous studies showed that polymorphisms in the il-13 gene were associated with serum total ige or allergic asthma. the relationship of this marker with sensitization to individual aeroallergens has not been evaluated.200111678850
characterization of a human h9n2 influenza virus isolated in hong kong.two h9n2 viruses were isolated, for the first time, from humans in hong kong in 1999. isolation of influenza viruses with a novel subtype of the hemagglutinin (ha) drew attention of health care authorities worldwide from the view of pandemic preparedness. sequence analysis of the ha genes reveals that ha of a/hong kong/1073/99 (h9n2) is most closely related to that of a/quail/hk/g1/97 (h9n2) that contains the internal genes similar to those of hong kong/97 (h5n1) viruses. phylogenetic and antige ...200111567756
comparisons of highly virulent h5n1 influenza a viruses isolated from humans and chickens from hong kong.genes of an influenza a (h5n1) virus from a human in hong kong isolated in may 1997 were sequenced and found to be all avian-like (k. subbarao et al., science 279:393-395, 1998). gene sequences of this human isolate were compared to those of a highly pathogenic chicken h5n1 influenza virus isolated from hong kong in april 1997. sequence comparisons of all eight rna segments from the two viruses show greater than 99% sequence identity between them. however, neither isolate's gene sequence was clo ...19989658115
rabies and quarantine. 19968938970
5 year statistics of animal and insect bites in hong kong.statistics of bites of patients in a rural district hospital in hong kong were accumulated over a 5 year period from 1984-1989. analysis revealed a predominance of dog bites. seasonal variations were noted for snake and insect bites, but not for dog bites. comparison was made with some uk data.19921545417
infectious canine hepatitis virus infections in dogs in hong kong. 1975164711
domestic exposure to aeroallergens in hong kong families with asthmatic children.indoor aeroallergen exposures increased asthma symptoms in caucasians, but their determinants and relationship to asthma and allergy in asians are unclear. this study investigated exposures to cat, cockroach, and blomia tropicalis allergens in 115 hong kong families with asthmatic children. patients underwent exhaled nitric oxide and spirometric measurements. home visits were made within 2 weeks during which parents completed a standardized questionnaire. fel d 1, bla g 2, and blo t 5 in dust sa ...201121634030
host-specific 16s rrna gene markers of bacteroidales for source tracking of fecal pollution in the subtropical coastal seawater of hong kong.this study investigated the diversity of bacteroidales communities in the feces of eight host species in hong kong (subtropical asia), including human (in the form of sewage), cow, pig, horse, cat, dog, rabbit and rat. the analysis of terminal restriction fragment length polymorphism (trflp) in the 16s rrna genes revealed significant differences in bacteroidales communities among all host species, with the exception of dog and cat. manual examination of trflp profiles resulted in six terminal re ...201020705317
detection of an oseltamivir-resistant pandemic influenza a/h1n1 virus in hong kong. 200919736041
methicillin-resistant commensal staphylococci in healthy dogs as a potential zoonotic reservoir for community-acquired antibiotic resistance.beta-lactam-resistant staphylococci evolved due to widespread nosocomial antibiotic use during the twentieth century, but the last decade has seen the emergence of genotypically distinct resistant bacteria outside hospitals, such as community-acquired methicillin-resistant staphylococcus aureus (ca-mrsa). this changing epidemiology suggests that mechanisms other than direct antibiotic selection could be involved in the spread of bacterial resistance. here we report a 17% prevalence of methicilli ...200919073283
melamine-tainted milk product (mtmp) renal stone outbreak in humans. 200819060339
investigation of the role of dogs as reservoirs of staphylococcus aureus and the transmission of strains between pet owners and their dogs. 200818941268
preliminary findings of a randomized trial of non-pharmaceutical interventions to prevent influenza transmission in households.there are sparse data on whether non-pharmaceutical interventions can reduce the spread of influenza. we implemented a study of the feasibility and efficacy of face masks and hand hygiene to reduce influenza transmission among hong kong household members.200818461182
retrospective study of old world screwworm fly (chrysomya bezziana) myiasis in 59 dogs in hong kong over a one year period.this retrospective study examined the case records of old world screw-worm fly myiasis in dogs in hong kong's new territories. myiasis due to owswf was identified and treated in 59 dogs at our clinic over a period of 1 year. signalment, causes of initial wound, and treatments implemented, are reported. all cases recovered from myiasis with a combination of larvae removal and wound debridement, antibiotics, and topical and systemic insecticides. whilst this parasite is currently exotic to austral ...200415149070
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