| in vitro anti-hiv and -hsv activity and safety of sodium rutin sulfate as a microbicide candidate. | sodium rutin sulfate (srs) is a sulfated rutin modified from the natural flavonol glycoside rutin. here, we investigated its in vitro anti-hiv and -hsv activities and its cytotoxic profile. fifty percent inhibitory concentration (ic(50)) values of srs against hiv-1 x4 virus iiib, hiv-1 r5 isolates ada-m and ba-l were 2.3+/-0.2, 4.5+/-2.0 and 8.5+/-3.8 microm with a selectivity index (si) of 563, 575 and 329, respectively. its ic(50) against primary r5 hiv-1 isolate from yunnan province in china ... | 2007 | 17459492 |