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evidence of dengue virus infection in a german couple returning from hawaii. 19989917181
dengue fever, hawaii, 2001-2002.autochthonous dengue infections were last reported in hawaii in 1944. in september 2001, the hawaii department of health was notified of an unusual febrile illness in a resident with no travel history; dengue fever was confirmed. during the investigation, 1,644 persons with locally acquired denguelike illness were evaluated, and 122 (7%) laboratory-positive dengue infections were identified; dengue virus serotype 1 was isolated from 15 patients. no cases of dengue hemorrhagic fever or shock synd ...200515890132
homology of complete genome sequences for dengue virus type-1, from dengue-fever- and dengue-haemorrhagic-fever-associated epidemics in hawaii and french polynesia.dengue epidemic virulence is thought to be conferred by various factors, including the genotype of the virus involved. increased or decreased epidemic virulence has been associated not only with the introduction of type-2 (denv-2) strains into the south pacific, the caribbean and south america, but also with newly emergent denv-3 genotypes in sri lanka, and the year-to-year variation in the denv-4 strains circulating in puerto rico. these observations indicate that there are inherent differences ...201020507696
spatially disaggregated disease transmission risk: land cover, land use and risk of dengue transmission on the island of oahu.vector-borne diseases persist in transmission systems that usually comprise heterogeneously distributed vectors and hosts leading to a highly heterogeneous case distribution. in this study, we build on principles of classical mathematical epidemiology to investigate spatial heterogeneity of disease risk for vector-borne diseases. land cover delineates habitat suitability for vectors, and land use determines the spatial distribution of humans. we focus on the risk of exposure for dengue transmiss ...201021073638
the burden of dengue and chikungunya worldwide: implications for the southern united states and california.dengue virus (denv) spreads to humans through the bite of an infected aedes aegypti or aedes albopictus mosquito and is a growing public health threat to both industrialized and developing nations worldwide. outbreaks of autochthonous dengue in the united states occurred extensively in the past but over the past 3 decades have again taken place in florida, hawaii, and texas as well as in american samoa, guam, northern mariana islands, puerto rico, and the us virgin islands. as the aedes vectors ...025960096
dengue in the united states of america: a worsening scenario?dengue is a febrile illness caused by any of the four dengue virus types (denv-1 to -4, genus flavivirus, family flaviviridae) mainly transmitted by the mosquito aedes aegypti. denv can be transmitted by blood transfusion. dengue has been historically present in the continental united states (us), in the state of hawaii, and in the us insular territories in the caribbean and the pacific. during the second half of the 20th century, most of the cases reported in the us were imported cases brought ...201323865061
return of epidemic dengue in the united states: implications for the public health practitioner.conditions that facilitate sustained dengue transmission exist in the united states, and outbreaks have occurred during the past decade in texas, hawaii, and florida. more outbreaks can also be expected in years to come. to combat dengue, medical and public health practitioners in areas with mosquito vectors that are competent to transmit the virus must be aware of the threat of reemergent dengue, and the need for early reporting and control to reduce the impact of dengue outbreaks. comprehensiv ...022547856
dengue risk among visitors to hawaii during an outbreak.despite the high rates of dengue in many tropical destinations frequented by tourists, limited information is available on the risk for infection among short-term visitors. we retrospectively surveyed 4,000 persons who arrived in hawaii during the peak of the 2001-2002 dengue outbreak and collected follow-up serologic test results for those reporting denguelike illness. of 3,064 visitors who responded, 94 (3%) experienced a denguelike illness either during their trip or within 14 days of departu ...015890133
history of aedes mosquitoes in hawaii.as a geographically isolated island chain with no native mosquitoes, hawaii is a model for examining the mechanisms behind insect vector invasions and their subsequent interactions with each other and with human populations. the yellow fever mosquito, aedes aegypti, and the asian tiger mosquito, ae. albopictus, have been responsible for epidemics of dengue in hawaii. as one of the world's earliest locations to be invaded by both species, hawaii's history is particularly relevant because both spe ...201323923330
underrecognition of leptospirosis during a dengue fever outbreak in hawaii, 2001-2002.during the 10-year period from 1997 through 2006, the reported mean annual incidence rate of leptospirosis in the state of hawaii was 3.3/100,000 with a range of 22-60 infections reported each year. because the clinical presentation is highly variable, however, leptospirosis illness is challenging to recognize and may be underdiagnosed. to assess whether the incidence may be substantially higher than reported figures indicate, we retrospectively studied the prevalence of anti-leptospira igm anti ...200818447625
antibody to dengue 1 detected more than 60 years after infection.we investigated the duration of humoral responses to dengue virus infection in individuals who recalled experiencing dengue fever-like illnesses at the time of the second world war, when dengue fever epidemics occurred throughout the pacific and southeast asia. in july 1943 dengue fever reappeared in hawaii following an interval of 31 years. over the next 12 months a total of 1498 locally transmitted cases were reported, and at least 46 imported cases were identified, most of which were among me ...200718158740
differential functional avidity of dengue virus-specific t-cell clones for variant peptides representing heterologous and previously encountered serotypes.proinflammatory cytokines secreted by memory cd8+ and cd4+ t cells are thought to play a direct role in the pathogenesis of dengue virus infection by increasing vascular permeability and thereby inducing the pathophysiologic events associated with dengue hemorrhagic fever and dengue shock syndrome. severe disease is frequently observed in the setting of secondary infection with heterologous dengue virus serotypes, suggesting a role for cross-reactive memory t cells in the immunopathogenesis of s ...200717626101
molecular epidemiology of dengue in the pacific: introduction of two distinct strains of dengue virus type-1 [corrected] into hawaii.in 2000, a major dengue epidemic, caused by the type-1 virus (denv-1), began in the pacific and asia, with cases still being reported in 2006. the phylogenetic analysis of full-length sequences of the envelope-protein gene of denv-1 isolates recovered during outbreaks in hawaii and tahiti in 2001-2002 indicated that most hawaiian isolates were tahitian in origin. all the hawaiian and tahitian isolates were identified as the pacific subtype (i.e. subtype iv) of denv-1. a hawaiian isolate, collect ...200616762113
risk factors for infection during a dengue-1 outbreak in maui, hawaii, 2001.autochthonous dengue virus transmission, last identified in the state of hawaii in 1945, was detected again in 2001. a seroepidemiological survey in a high-incidence community (nahiku) and a nearby low-incidence community (hana subdivision) was implemented. the two communities studied differed in median household size (two vs. four persons), median lot size (2.8 vs. 0.8acres), proportion of households with mosquito larvae (81 vs. 28%) and incidence of recent infection (39% [28/72] vs. 1% [1/131] ...200616356519
biologic properties of dengue viruses following serial passage in primary dog kidney cells: studies at the university of hawaii.serial passage at low dilution of seven different wild-type dengue (den) viruses into primary dog kidney (pdk) cell cultures placed selective pressure that resulted in the following changes from parental phenotype: smaller plaques in llc-mk2 cells, absent plaque formation in green monkey kidney cells, lack of a cytopathic effect in llc-mk2 cells, shut-off of virus replication at high temperatures (temperature sensitivity), reduced virulence for rhesus monkeys manifested by reduced or absent vire ...200314740949
genetics of aedes albopictus.aedes albopictus is an important vector of dengue fever and dengue hemorrhagic fever in southeast asia. its distribution extends from madagascar to hawaii and is currently expanding. from its proposed origin in southeast asia, ae. albopictus has migrated as far as mauritius and madagascar to the west and korea, japan, guam, hawaii and other pacific islands to the east. in the continental united states, it was originally reported in the texas area in august 1985 and is now well established in sev ...19863333792
notes from the field: outbreak of locally acquired cases of dengue fever--hawaii, 2015.on october 21, 2015, the hawaii department of health (hdoh) was notified of a positive dengue immunoglobulin m (igm) antibody result in a woman residing on hawaii island (also known as the big island). the patient had no history of travel off the island, and other family members reported having similar signs and symptoms, which consisted of fever, headache, myalgias and arthralgias, and a generalized erythematous rash. hdoh initiated an investigation to identify any additional cases and potentia ...201626796994
update: the diagnosis and management of dengue virus infection in north america.dengue is a mosquito-transmitted infection that poses significant global health risks for travelers and individuals living in the tropics and subtropics. the reported global incidence has increased dramatically in the past century, with dengue now ranking as the most common cause of febrile illness in travelers. while sporadic cases have been reported within the southern united states since 1980, autochthonous outbreaks have now been described in hawaii, st. croix (us virgin islands), along the ...201222541792
lessons learned during dengue outbreaks in the united states, 2001-2011.since 2001, three autochthonous dengue fever outbreaks have occurred in the united states: in hawaii (2001); brownsville, texas (2005); and southern florida (2009-2011). we sought to characterize and describe the response to these outbreaks from the perspectives of public health and vector control officials. by conducting a medical literature review through pubmed and news media searches through google, we identified persons involved in managing each outbreak; 26 persons then participated in qua ...022469195
control of dengue in hawaii. 194720242031
studies of dengue fever virus (hawaii mouse adapted) in lactating hamsters. 195613362747
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