| epidemiology of tropical spastic paraparesis in columbia and associated htlv-i infection. | the clinical syndrome earlier designated as paraparesia espástica del pacífico is an isolated form of tropical spastic paraparesis (tsp) that was reported in 1981 in the southern pacific lowlands of columbia in and near tumaco. the clinical features are similar to those of tsp reported in jamaica, martinique, the seychelles, and the ivory coast of africa and resemble also those clinical features of the human t-lymphotropic virus type i (htlv-i)-associated myelopathy described in southern japan. ... | 1988 | 2894809 |
| tropical spastic paraparesis/htlv-i associated myelopathy. etiology and clinical spectrum. | in 1985 we had the first indication that human t-cell lymphotropic virus (htlv-i) was the possible etiological agent of a chronic myelopathy that seemed to be peculiar to the tropics and that is now known as endemic tropical spastic paraparesis (tsp). igg antibodies to htlv-i were found in serum and cerebrospinal fluid of patients from jamaica, colombia, martinique, and shortly after in southern japan, where the disease is called htlv-i-associated myelopathy (ham). the htlv-i seropositivity was ... | 1994 | 7999314 |
| tropical spastic paraparesis: clinical, immunological, and virological studies in two patients from martinique. | two patients from martinique with tropical spastic paraparesis had antibodies to human t-lymphotropic virus type i (htlv-i) in serum and spinal fluid but no antibodies to other retroviruses tested. they presented with spastic weakness of both lower extremities, hyperreflexia with upgoing toes, sphincteric dysfunction, and normal sensation. by means of agarose isoelectric focusing and selective immunoblotting we demonstrated an increased intrathecal synthesis of igg antibodies to htlv-i in the sp ... | 1988 | 2894805 |
| htlv-i-associated tropical spastic paraparesis in martinique: a reappraisal. | human t-lymphotropic virus type i (htlv-i)-associated tropical spastic paraparesis in martinique has been identified in 54 patients, 49 women and 5 men. this myelopathy represents an endemic problem on this island and the earliest documented case dates from 1952. a blood transfusion history was obtained in 7 of the 54 patients (13%). there was a preponderance of cases from the northern atlantic coast of martinique, the most humid region on the island. the prevalence in this region reached 49.5 p ... | 1988 | 2894804 |
| retrovirus-associated myelopathies. | human t-lymphotropic virus type i (htlv-i), the causative agent of adult t-cell leukemia and non-hodgkin's lymphoma (atll)--or a cross-reacting retrovirus--has been associated with tropical spastic paraparesis in martinique, jamaica, colombia, trinidad and tobago, the seychelles, and probably also in zaire. the caribbean basin and sub-saharan africa are endemic for atll. a similar etiology has been invoked in a chronic spastic myelopathy occurring in areas of high atll endemicity in japan. an ht ... | 1987 | 2883964 |
| htlv-i antibody and cell-mediated immunity status in sickle cell anemia. | patients with sickle cell anemia (sca) had an abnormal susceptibility to infections. in martinique (french west indies), a human t-cell leukemia/lymphoma virus type i (htlv-i) endemic area, we found that 17 (10%) of 173 sca patients had antibodies to htlv-i. the possible relationship between htlv-i seropositivity and altered immunity was studied in 13 sca patients with htlv-i antibodies compared with 13 matched sca patients without htlv-i antibodies. the immunological results, as evaluated by th ... | 1987 | 2881638 |
| [paraplegia associated with htlv-1 virus]. | human t-cell leukaemia virus (htlv) has been found to be endemic in the caribbean islands. so-called spastic paraplegia of unknown origin, described in martinique (named tropical spastic paraplegia in other countries) was found to be associated with signs of htlv-l infection in 1984-1985. this association has since been found in non-tropical countries, particularly in japan where htlv-l is endemic. numerous questions about the physiopathology of the neurological involvement and the systemic symp ... | 1989 | 2660218 |
| diagnosis of htlv-i infected seronegative neurological patients by polymerase chain reaction amplification in martinique. | htlv-i is a type c human retrovirus, endemic in japan, central africa, south america and the caribbean, which causes adult t cell leukemia/lymphoma and chronic progressive paraparesis. some neurological patients with chronic progressive myelopathies, but seronegative for htlv-i have been reported in martinique. we performed polymerase chain reaction (pcr), to look for the presence of htlv-i genomic sequences in those patients. two primers were chosen for gag and tax genes. liquid hybridization w ... | 1990 | 2349077 |
| sex ratio of human t-lymphotropic virus type i infection and blood transfusion. | the prevalence of human t-lymphotropic virus type i (htlv-i) infection is higher for females than for males. blood transfusion is a potential confounding factor which might contribute to this high female:male ratio. two studies were performed in martinique (french west indies) to clarify this issue: a case-control survey comparing the experience of previous blood transfusion among 62 htlv-i-seropositive and 88 htlv-i-seronegative blood donors, and a retrospective study of the sex of recipients o ... | 1990 | 2301349 |
| [atypical lumbar and nerve-root pain associated with the htlv-1 virus]. | the human retrovirus htlv-1 (human t-cell lymphotrophic virus) is responsible for malignant proliferations of mature t lymphocytes. it is also now implicated in neurological disorders dominated by spastic paraplegia. a study of 140 cases of lumbar and root pain enabled us to identify 8 of apparently idiopathic atypical lumbar and root pain which led to the discovery of a positive htlv-1 serology performed routinely. these cases were remarkable in terms of the rarity and minimal extent of spinal ... | 1990 | 2150450 |
| [investigation of a transfusion contaminated by htlv-i virus]. | in front of the successive development of an htlv-i seroconversion and a neuromyelopathy in a french caucasian following a cardiac transplantation, an ascendant epidemiologic investigation must be manage to search a risk factor or a possible blood donor contaminated with htlv-i virus. we selected an htlv-i seropositive donor whose rbc participated to the patient's transfusion. this woman from martinique island was a regular donor in our blood center and a second investigation was initiated to ex ... | 1991 | 2064686 |
| absence of consistent association between human leukocyte antigen-i and -ii alleles and human t-lymphotropic virus type 1 (htlv-1)-associated myelopathy/tropical spastic paraparesis risk in an htlv-1 french afro-caribbean population. | human t-cell lymphotropic virus type 1 (htlv-1) infection leads to the risk of developing htlv-1-associated myelopathy/tropical spastic paraparesis (ham/tsp) in less than 5% of cases. the mechanism of disease progression in ham/tsp remains unknown. a significant role of certain human leukocyte antigen (hla) genotypes in determining the risk of ham/tsp has been reported in japan, where the hla-a*02 gene has been found to be associated with a lower htlv-1 provirus load and with protection from ham ... | 2010 | 20851016 |
| htlv-i infection in french west indies: a case-control study. | a case-control study was performed in martinique, french west indies, comparing 66 anti-p24 antibody carriers to 91 seronegative subjects for htlv-i, matched for age and place of residence. the aim of our study was to identify factors associated with htlv-i infection and to observe whether clinical examination and biological measurements would reveal any abnormalities among the seropositive subjects. we observed a predominance of females among seropositive subjects (74% compared to 59%, p less t ... | 1991 | 2044716 |
| high human t-cell lymphotropic virus type i proviral dna load with polyclonal integration in peripheral blood mononuclear cells of french west indian, guianese, and african patients with tropical spastic paraparesis. | human t-cell lymphotropic virus type i (htlv-i) proviral integration status was examined by southern blot analysis in peripheral blood mononuclear cell (pbmc) dna from patients presenting a tropical spastic paraparesis (tsp) and serological evidence of htlv-i infection. surface phenotype and morphological aspects of pbmc were also studied. a polyclonal htlv-i proviral integration was found in the pbmc of the 10 patients studied irrespective of their geographical origin (french west indies, frenc ... | 1990 | 1967218 |
| [neurologic manifestations related to htlv-1 viruses]. | the human t-cell leukaemia virus type 1 was the first human retrovirus to be isolated in 1980 by r. gallo and coworkers. as its name indicates, this virus is responsible for adult t-cell leukaemia. in 1985, the neurological manifestations associated with this disease were isolated from the tropical spastic paraplegia group in martinique. since that time, such manifestations have been reported in non-tropical countries in other foci of viral endemia and sporadically outside these regions. these n ... | 1991 | 1792435 |
| [sarcoidosis and leukemia/t-cell lymphoma associated with htlv-1 virus infection in adults (apropos of a case)]. | the htlv-1 virus causes a disturbance of the immune system, the evaluation of which is often difficult. we report a case of sarcoidosis in a 49 year old woman of martinique as evidenced by bilateral hilar adenopathy, hypercalcaemia, uveitis and granulomatous lesions on histological examination. serological was positive for htlv-1 antibodies. three years later she developed an adult t-cell leukemia/lymphoma. the relationships between the htlv-1 retroviral infection and different pathologies obser ... | 1992 | 1287773 |
| human t cell leukemia virus type i expression in salivary glands of infected patients. | human t cell leukemia virus type i (htlv-i) sequences were sought in labial salivary glands of patients with htlv-i-associated myelopathy or tropical spastic paraparesis and of seropositive neurologically healthy carriers. htlv-i proviral dna was found by polymerase chain reaction amplification in dna extracted from lip biopsies of every patient. viral rna was found by in situ hybridization in the acini epithelium, as well as in lymphocytic infiltrates. this observation suggests that htlv-i expr ... | 1999 | 9878038 |
| hiv/htlv-i coinfection and clinical grade at diagnosis. | a total of 963 hiv-infected patients have been identified or followed up in martinique since 1985. medical files were used to retrieve information about age, sex, circumstances of diagnosis, htlv-i status, and hiv clinical grade at first examination according to cdc criteria from 1987. complete information was available for 774 patients. at the first clinical examination, the clinical grade of 65 coinfected patients was more severe than that of the monoinfected patients (giv versus gii, or = 2.6 ... | 1995 | 8548352 |
| identification of novel neutralization-inducing regions of the human t cell lymphotropic virus type i envelope glycoproteins with human htlv-i-seropositive sera. | the humoral immune response in sera from 30 human t cell lymphotropic virus type i (htlv-i)-positive individuals from martinique in the french west indies was studied. the subjects were subdivided into those suffering from tsp/ham and those being asymptomatic. in general, tsp/ham patient sera seemed to contain more virus-specific antibodies than did the sera from the asymptomatic subjects. three of the 13 tsp/ham sera and 1 of the 17 asymptomatic sera contained htlv-i-specific igm antibodies, wh ... | 1994 | 8198868 |
| htlv-i maternal transmission in martinique, using serology and polymerase chain reaction. | we have investigated htlv-i and htlv-ii infection in children born to htlv-i-seropositive or indeterminate western blot mothers in martinique by using the polymerase chain reaction (pcr). only htlv-i and no htlv-ii-positive samples were found in this study. all the samples from htlv-i-seropositive children and adults were pcr positive, whereas the four hiv-i-seropositive and western blot htlv-i-negative mothers and their eight children were all pcr negative. therefore, pcr and serology were in c ... | 1993 | 7903044 |
| sequence and phylogenetic analyses of human t cell lymphotropic virus type 1 from a brazilian woman with adult t cell leukemia: comparison with virus strains from south america and the caribbean basin. | human t cell lymphotropic virus type 1 (htlv-1) is endemic in south america and the caribbean basin. to clarify the genetic and phylogenetic relationship between an htlv-1 strain isolated from a brazilian woman with adult t cell leukemia and viral isolates from elsewhere in south america and from other geographic regions, selected regions of the gag, pol, env, and px genes were amplified and directly sequenced. the overall sequence similarities between the brazil-r-1 strain and the japanese prot ... | 1995 | 7856818 |
| [paraplegia associated with htlv 1 in martinique. study of 271 cases including 70 with neuromuscular involvement]. | to date, 271 cases of htlv1-associated paraplegia have been observed in martinique (french west indies). the clinical picture consisted mostly in a spastic paraparesis or paraplegia with sphincter disturbances (80%) and lower limbs pains (60%). the severity of the disease appeared variable: after a mean disease duration of 6.5 years, 40% of the patients could walk without help, 35% used a single crutch, and 25% used a couple of crutches or were confined to a wheelchair. a variable neuromuscular ... | 1993 | 7819796 |
| polyarthritis in htlv-1-infected patients. a review of 17 cases. | a retrospective study was conducted in martinique to identify patients with polyarthritis and positive serologic tests for the human t-cell lymphotropic virus type i (htlv-1). patients with metabolic or bacterial causes of polyarthritis were excluded. we found 17 cases of htlv-1-positive polyarthritis (6.7% of the total of polyarthritis patients followed in our department); there were 14 females and three males, and all the patients were west-indian blacks. mean age at diagnosis was 50 years. fi ... | 1995 | 7788319 |
| antibodies to htlv-i p24 in sera of blood donors, elderly people and patients with hemopoietic diseases in france and in french west indies. | human t-cell lymphoma/leukemia virus type i (htlv-i) is a type-c retrovirus originally isolated from patients with leukemia or lymphoma involving mature t lymphocytes. epidemiological studies have shown that htlv-i infection occurs not only in leukemic but also in normal people in at least two areas of the world: the caribbean basin and the south-west of japan. we report here the results of a large seroepidemiological study of htlv-i infection in normal french blood donors, elderly subjects livi ... | 1984 | 6094365 |
| [prevalence of htlv-1 virus in pregnant women in black africa, martinique, and foreigners living in france]. | | 1988 | 3056585 |
| endemic tropical spastic paraparesis associated with human t-lymphotropic virus type i: a clinical and seroepidemiological study of 25 cases. | tropical spastic paraparesis (tsp) is a common myeloneuropathy with primary and predominant involvement of the pyramidal tract and minimal sensory loss. the epidemic form of tsp is related to toxic nutritional factors, but the endemic form occurs in clusters in tropical areas, especially in india, africa, the seychelles, colombia, and areas of the caribbean. we describe the clinical and epidemiological features of 25 tsp patients from martinique (french west indies) with serum antibodies to huma ... | 1987 | 3030190 |
| [adult t-cell lymphoma/leukemia associated with htlv-i virus in martinique: apropos of 2 cases]. | two htlv-i associated adult t cell leukemia cases were observed in patient from martinique (french west indies). these case are similar to the clinical entity, described by takatsuki in 1977 in japan and by catovsky in caribbean patients, characterized by a lymphadenopathy, skin lesions and visceral involvement, hypercalcemia, an aggressive course, and poor prognosis. the malignant cells with t4 phenotype and often suppressive function, were pleomorphic, mature, with prominent nuclear irregulari ... | 1986 | 3016639 |
| [tropical spastic paraparesis in martinique. high prevalence of anti-htlv-i antibodies]. | owing to the frequent occurrence in tropical countries of subacute spinal cord diseases of unknown origin, a nosological entity called tropical spastic paraparesis has been individualized. twenty-two cases have been observed in martinique. the presence in the serum of antibodies directed against human t-cell leukaemia/lymphoma virus (htlv-i) in 15 of these 22 patients suggests that this lymphotropic virus or a related one might also be neurovirulent. | 1986 | 3008147 |
| implication of htlv-i infection, strongyloidiasis, and p53 overexpression in the development, response to treatment, and evolution of non-hodgkin's lymphomas in an endemic area (martinique, french west indies). | a clinicopathologic study was conducted to assess the implication of htlv-i infection, strongyloides stercoralis (ss) infection, and p53 overexpression in the development, response to treatment, and evolution of non-hodgkin's lymphoma (nhl) in martinique, french west indies. two groups of patients, with 22 and 41 participants with b-cell and t-cell lymphoma, respectively, were analyzed. htlv-i antibodies were detected in 24 (59%) patients with t-cell lymphoma of whom 19 (46%) fulfilled diagnosti ... | 1999 | 10096585 |
| seroindeterminate patterns and seroconversions to human t-lymphotropic virus type i positivity in blood donors from martinique, french west indies. | screening for human t-lymphotropic virus type i (htlv-i) antibodies in volunteer blood donors has been systematic in the french west indies since 1989. western blot-indeterminate results are commonly obtained. the significance of these indeterminate serologic patterns in htlv-i-endemic areas is still unclear. | 1999 | 10532611 |
| seroprevalence of retroviral infections among pregnant women in martinique (french west indies). | a seroepidemiologic study of human t cell lymphotrophic virus type-1 (htlv-1) and human immunodeficiency virus (hiv) infections was carried out in martinique among 467 pregnant women receiving prenatal care at the martinique department for the protection of motherhood and childhood. a seroprevalence rate of 1.93% was found for htlv-1 infection. no hiv serum marker was observed. given the epidemiology of these viral diseases, it is suggested that serologic status should be determined for all preg ... | 1999 | 10548294 |
| incidence of hematological malignancies in martinique, french west indies, overrepresentation of multiple myeloma and adult t cell leukemia/lymphoma. | a registry of hematological malignancies is held in the unit of cytology of the university hospital of martinique. human t cell lymphotropic virus type-1 (htlv1) is endemic in this island. we determined the incidence and epidemiological features of hematological malignancies from the 715 new cases diagnosed between 1990 and 1998 among the adult population. incidence rates per year were steady during this period. the most frequent hematological malignancies were multiple myeloma (mm) (34%), follo ... | 2001 | 11368445 |
| ocular lesions in 200 patients infected by the human t-cell lymphotropic virus type 1 in martinique (french west indies). | to describe the ophthalmologic features observed in patients infected by the human t-cell lymphotropic virus, type 1 (htlv-1) in martinique (french west indies). | 2002 | 12140025 |
| evaluation of htlv-i removal by filtration of blood cell components in a routine setting. | wbc depletion by filtration may prevent the transmission of htlv-i, which requires cell-to-cell contact. the removal of htlv-i-infected cells in routinely filtered blood cell components was measured. | 2004 | 14692966 |
| retinal vasculitis caused by adult t-cell leukemia/lymphoma. | to report a case of lymphomatous infiltration and bilateral retinal vasculitis observed among 83 cases of adult t-cell leukemia (atl) treated in the university hospital center in fort-de-france (martinique, french west indies) between 1984 and 2003. | 2005 | 15692773 |
| meta-analysis on the use of zidovudine and interferon-alfa in adult t-cell leukemia/lymphoma showing improved survival in the leukemic subtypes. | human t-cell lymphotropic virus type-i-associated adult t-cell leukemia/lymphoma (atl) is an aggressive, chemotherapy-resistant malignancy. multiple small studies using zidovudine (azt) and interferon-alfa (ifn-α) have shown response in patients with atl. however, the impact of this innovative antiviral treatment strategy on long-term survival remains undetermined. | 2010 | 20585095 |