| common origin of human t-lymphotropic virus type-i from iran, kuwait, israel, and la réunion island. | we found previously that kuwaiti htlv-i isolates had two nucleotide substitutions in the most frequently sequenced regions of htlv-i genome, namely: t-->c 4783 in the pol and t-->c 6569 the env genes. these substitutions were observed rarely in other htlv-i isolates and seemed to be good markers of the htlv-i lineage, the "epicentre" of which was located in mashhad, iran. to test this hypothesis we sequenced the fragments of htlv-i genome including sites 4783 and 6569 from seven isolates obtaine ... | 1997 | 9131461 |
| molecular characterization of human t-lymphotropic virus, type 1 (htlv-1) found in kuwait: close similarity with htlv-1 isolates originating from mashhad, iran. | human t-lymphotropic virus, type 1 (htlv-1) infection was detected in two unrelated kuwaiti patients with tropical spastic paraparesis (ham/tsp) and in the asymptomatic mother of one of them. the family roots of these patients were traced to the najaf region of iraq. the dna sequence of three pcr-amplified fragments (env, 512 bp; pol, 140 bp; ltr, 704 bp) was determined for each of kuwaiti htlv-1 isolates (kuw-1,2,3). all three kuwaiti htlv-1 were identical in env and pol fragments and virtually ... | 1995 | 8573383 |
| phylogenetic classification of human t cell leukaemia/lymphoma virus type i genotypes in five major molecular and geographical subtypes. | proviral dna was obtained from ex vivo peripheral blood mononuclear cells of 75 human t cell leukaemia/lymphoma virus type i (htlv-i)-infected individuals who were either asymptomatic or had adult t cell leukaemia or tropical spastic paraparesis/htlv-i-associated myelopathy. amplified long terminal repeats (ltrs) were analysed for restriction fragment length polymorphisms (rflps). the results, together with previously published ltr data (a total of 180 specimens analysed), showed the presence of ... | 1994 | 7996161 |
| seroepidemiology, viral isolation, and molecular characterization of human t cell leukemia/lymphoma virus type i from la réunion island, indian ocean. | data indicate the presence in the seychelles islands of a high level of human t cell leukemia/lymphoma virus type i (htlv-i) endemicity as well as the presence of tropical spastic paraparesis/htlv-i-associated myelopathy (tsp/ham). we present here the results of an hospital survey performed since 1988 in la réunion island, located in the indian ocean southeast of the seychelles archipelago, aimed at evaluating htlv-i endemicity, detecting htlv-i-associated diseases, and characterizing viral isol ... | 1994 | 7915530 |