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the complex between tpa and pai-1: risk factor for myocardial infarction as studied in the sheep project.the tpa/pai-1 complex seems to be an important biochemical marker for myocardial reinfarction. therefore we explored the distribution, correlation and interaction of plasma concentrations of tpa/pai-1 complex in all available patients and matched controls in the stockholm heart epidemiology program (sheep).200515935831
neighborhood socioeconomic context, individual income and myocardial infarction.the incidence of myocardial infarction (mi) varies among socioeconomic groups, and geographic differences in incidence rates are observed within most urban regions. whether spatial social differentiation gives rise to social contexts detrimental to health is still an open question. in this study, we evaluate 2 aspects of the neighborhood context as contributory factors in mi: level of economic resources and degree of socioeconomic homogeneity. we adopt a multilevel approach to analyze potential ...200616357590
occupational magnetic field exposure and myocardial infarction incidence.studies on healthy volunteers have seen reduced heart rate variability after exposure to extremely low-frequency electric and magnetic fields (emf). because reduced heart rate variability has been linked to cardiovascular disease risk, it has been hypothesized that exposure to emf might increase the risk of cardiovascular disease. one epidemiologic study has shown increased mortality from cardiovascular conditions in utility workers with elevated exposure to magnetic fields, but several other ep ...200415232399
the effect of leisure-time physical activity on the risk of acute myocardial infarction depending on body mass index: a population-based case-control study.high body mass index (bmi) and lack of physical activity have been recognized as important risk factors for coronary heart disease. the aim of the present study was to evaluate whether leisure-time physical activity compensates for the increased risk of acute myocardial infarction associated with overweight and obesity.200617156418
misclassification of occupation-based socioeconomic position and gender comparisons of socioeconomic risk.because occupational classification systems tend to be less precise in the female sector of the working market there has been concern that this might imply more misclassification of socioeconomic position among women, biasing comparisons of gender-specific socioeconomic differences in risk.200717366083
abstention, alcohol use and risk of myocardial infarction in men and women taking account of social support and working conditions: the sheep case-control study.very few studies indicating that low-moderate alcohol consumption protects from myocardial infarction (mi) controlled for social support and working conditions, which could confound the findings. therefore, a first aim was to study the risk of non-fatal and total mi in relation to volume of alcohol consumption and measures of social support and working conditions. a second aim was to analyse the impact of the volume of earlier alcohol use in abstainers.200314519183
contextual effects of social fragmentation and material deprivation on risk of myocardial infarction--results from the stockholm heart epidemiology program (sheep).socioeconomic deprivation has been suggested as a contextual feature of importance for cardiovascular disease and mortality, whereas the effect of social fragmentation has largely been studied in relation to suicide. in this study we examine the contextual effects of social fragmentation and material deprivation on the incidence of myocardial infarction (mi).200415155706
multivitamin supplements are inversely associated with risk of myocardial infarction in men and women--stockholm heart epidemiology program (sheep).epidemiologic data relating multivitamin supplement use to the risk of cardiovascular disease are sparse and inconsistent. we examined the association between self-selected use of low dose multivitamin supplements and the risk of myocardial infarction (mi). our results are based on data from a large population-based, case-control study of subjects aged 45-70 y residing in sweden, a country in which consumption of fruits and vegetables is relatively low and foods are not fortified with folic acid ...200312888653
pai-1 level and the pai-1 4g/5g polymorphism in relation to risk of non-fatal myocardial infarction: results from the stockholm heart epidemiology program (sheep).this study examines the relationship between plasma plasminogen activator inhibitor-1 (pai-1) activity and the pai-1 4g/5g polymorphism, and their association with the risk of myocardial infarction (mi). furthermore, this study explores whether a high level of pai-1 or whether the pai-1 4g/5g polymorphism synergistically interacts with any established environmental risk factor for mi. this case-referent study of subjects aged 45-70 and living in stockholm includes 851 men and 361 women with firs ...200312783120
association of boiled and filtered coffee with incidence of first nonfatal myocardial infarction: the sheep and the vheep study.to evaluate the influence of consumption of filtered and boiled coffee, on the incidence of first nonfatal myocardial infarction.200312755961
is the association between short stature and myocardial infarction explained by childhood exposures--a population-based case referent study (sheep).this study was undertaken to examine the association between short stature and acute non-fatal myocardial infarction and to analyse causal mechanisms related to height with a focus on childhood risk factors.200212680500
family history of coronary heart disease, a strong risk factor for myocardial infarction interacting with other cardiovascular risk factors: results from the stockholm heart epidemiology program (sheep).we explored the relation between family history of coronary heart disease and the risk of myocardial infarction in a case-control study of subjects, 45 to 70 years of age, living in stockholm, sweden. our cases comprised 1091 male and 531 female first-time acute myocardial infarction patients who had survived at least 28 days after their infarction. referents were randomly selected from the population from which the cases were derived. the adjusted odds ratio (or) of myocardial infarction was 2. ...200111246583
a population-based case-referent study of myocardial infarction and occupational exposure to motor exhaust, other combustion products, organic solvents, lead, and dynamite. stockholm heart epidemiology program (sheep) study group.this case-referent study investigated the risk of myocardial infarction from occupational exposure to motor exhaust, other combustion products, organic solvents, lead, and dynamite. we identified first-time, nonfatal myocardial infarctions among men and women 45-70 years of age in stockholm county from 1992 through 1994. we selected referent subjects from the population to match the demographic characteristics of the cases. a lifetime history of occupations was obtained by questionnaire. the res ...200111246584
do episodes of anger trigger myocardial infarction? a case-crossover analysis in the stockholm heart epidemiology program (sheep).our objectives were to study anger as a trigger of acute myocardial infarction (mi) and to explore potential effect modification by usual behavioral patterns related to hostility.199910593637
environmental tobacco smoke and myocardial infarction among never-smokers in the stockholm heart epidemiology program (sheep).an increased risk for myocardial infarction (mi) related to environmental tobacco smoke (ets) exposure has previously been reported, but several aspects of the association are still uncertain. we studied the mi risk associated with ets exposure among 334 nonfatal never-smoking mi cases and 677 population controls, 45-70 years of age, in stockholm county. a postal questionnaire with a telephone follow-up provided information on ets exposure and other potential risk factors for mi. after adjustmen ...200111505176
association between job characteristics and plasma fibrinogen in a normal working population: a cross sectional analysis in referents of the sheep study. stockholm heart epidemiology program.to explore the association between job characteristics and plasma fibrinogen concentrations.199910396481
plasma levels of tissue plasminogen activator/plasminogen activator inhibitor-1 complex and von willebrand factor are significant risk markers for recurrent myocardial infarction in the stockholm heart epidemiology program (sheep) study.an impaired fibrinolytic function due to elevated plasma levels of plasminogen activator inhibitor (pai)-1 activity or tissue plasminogen activator (tpa) antigen is correlated with the development of myocardial infarction (mi) in patients with manifest coronary heart disease. recently, methods for determining the specific tpa/inhibitor complexes constituting tpa antigen in plasma have become available. in the stockholm heart epidemiology program (sheep) study, 86 of 1212 mi patients, subjected t ...200010938026
higher relative, but lower absolute risks of myocardial infarction in women than in men: analysis of some major risk factors in the sheep study. the sheep study group.middle-aged men have often been the subjects of multifactorial studies of myocardial infarction (mi) risk factors. one major objective of the sheep study was to compare the effects of different mi risk factors in women and men.199910447785
socioeconomic differences in risk of myocardial infarction 1971-1994 in sweden: time trends, relative risks and population attributable risks.the general trend in incidence of myocardial infarction (mi) in the stockholm area changed from increasing to decreasing around 1980. the objective of this study is to examine time trends in incidence in major socioeconomic strata, relative risk between socioeconomic groups and population risk attributable to socioeconomic differences during this period.19989698128
is the effect of job strain on myocardial infarction risk due to interaction between high psychological demands and low decision latitude? results from stockholm heart epidemiology program (sheep).the objectives are to examine if the excess risk of myocardial infarction from exposure to job strain is due to interaction between high demands and low control and to analyse what role such an interaction has regarding socioeconomic differences in risk of myocardial infarction. the material is a population-based case-referent study having incident first events of myocardial infarction as outcome (sheep: stockholm heart epidemiology program). the analysis is restricted to males 45-64 yr of age w ...19989665570
decision latitude, job strain, and myocardial infarction: a study of working men in stockholm. the sheep study group. stockholm heart epidemiology program.this study examined the role of decision latitude and job strain in the etiology of a first myocardial infarction.19989518968
primary risk factors influence risk of recurrent myocardial infarction/death from coronary heart disease: results from the stockholm heart epidemiology program (sheep).prognosis after a first myocardial infarction (mi) is influenced by primary risk factors as well as secondary risk factors. there is still a lack of follow-up studies of well-characterized patient cohorts assessing the relative importance of these factors.200717667644
variants in the coagulation factor 2 receptor (f2r) gene influence the risk of myocardial infarction in men through an interaction with interleukin 6 serum levels.thrombin-activated factor 2 receptor (f2r) links thrombosis to inflammation modulating interleukin (il)6 synthesis. we have investigated the role of f2r genetic variants and their interaction with il6 serum levels in the occurrence of myocardial infarction (mi) in the stockholm heart epidemiology program (sheep). seven snps -1738 g/a, -506-/ggccgcgggaagc (d/i), 2860 g/a, 2930 t/c, 9113 c/a, 9333 c/t and 120813 t/c within f2r locus were genotyped in the sheep (n=2,774). the c allele at position 2 ...200919404549
biospheric 129i concentrations in the pre-nuclear and nuclear age.in order to detect characteristic regional differences or temporal changes of 129i concentrations in the biosphere, thyroids from humans, grazing livestock, and herbivorous wildlife species (reindeer and roedeer) were collected in various areas of the world which are not affected by reprocessing plants. for reasons of comparison, all samples were analyzed for their 129i:127i atom ratios. human and bovine thyroids taken from the 10th region in southern chile (39 degrees-41 degrees south) indicate ...19938244695
is disturbed sleep a mediator in the association between social support and myocardial infarction?the objective of this study was to investigate a mediating relationship between social support and disturbed sleep in cases surviving myocardial infarction. the case-referent studies, stockholm heart epidemiological program (sheep) and västernorrland heart epidemiological program (vheep) were used comprising 6231 participants (2046 women). referents were randomly selected. disturbed sleep was operationalized by the karolinska sleep questionnaire, network support by the availability of social int ...200818086718
accumulation of adverse socioeconomic position over the entire life course and the risk of myocardial infarction among men and women: results from the stockholm heart epidemiology program (sheep).accumulation of adverse socioeconomic position over the life course is assumed to increase the risk of myocardial infarction.200617108306
allelic variants of cytochromes p450 2c modify the risk for acute myocardial infarction.summary: cytochromes p450 (cyp) 2c8 and 2c9 are polymorphic enzymes responsible for the biosynthesis of vasoactive substances from arachidonic acid including endothelium-derived hyperpolarizing factor. inter-individual differences in the action of these substances might be important in the pathogenesis of cardiovascular diseases such as acute myocardial infarction (ami) and hypertension. this study describes the relationship between genetic variants of cyp2c8 and cyp2c9, and morbidity in myocard ...200314646690
socioeconomic context in area of living and risk of myocardial infarction: results from stockholm heart epidemiology program (sheep).to analyse if socioeconomic characteristics in area of living affect the risk of myocardial infarction in a swedish urban population, and to evaluate to what extent the contextual effect is confounded by the individual exposures.200211801617
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