| the immunodominant brugia malayi paramyosin as a marker of current infection with wuchereria bancrofti adult worms. | the full-length cdna sequence encoding brugia malayi l3 paramyosin has been isolated by immunoscreening a cdna library with a mouse antiserum raised against wuchereria bancrofti l3 infective larvae. a recombinant truncated form of paramyosin was expressed as a glutathione s-transferase fusion protein and used to evaluate humoral responses of adults from a w. bancrofti-endemic area in french polynesia according to their parasitological status. immunoglobulin g4 (igg4) preferentially bound to para ... | 1998 | 9596759 |
| evidence for protective immunity to bancroftian filariasis in the cook islands. | to challenge the concept of protective immunity in lymphatic filariasis, 19 adult residents of a wuchereria bancrofti-endemic island who had been diagnosed 17 years earlier as putatively immune endemic normals (pi/en) were reexamined. even with continued exposure to infection, all 19 had maintained their apparent infection-free status. studies to define the mechanisms underlying this putative immunity revealed that cellular immune responses (including proliferation; generation of interleukin [il ... | 1996 | 8769619 |
| wuchereria bancrofti filariasis in french polynesia: age-specific patterns of microfilaremia, circulating antigen, and specific igg and igg4 responses according to transmission level. | the age-specific patterns of microfilaremia, og4c3 antigenemia, anti-brugia malayi igg and igg4 were assessed in 3 villages of low, medium and high transmission level for wuchereria bancrofti filariasis. the prevalence rates for each of the 4 markers were clearly age dependent and their patterns strongly associated with the transmission level. the antigenemia prevalence rate was consistently higher than the microfilaremia prevalence rate, in all age groups. the prevalences of anti-b. malayi igg ... | 1995 | 7797377 |