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helicobacter pylori infection in childhood: risk factors and effect on growth.to investigate the current prevalence of helicobacter pylori infection in childhood, the risk factors for infection, and the effect of infection on growth in preadolescent schoolchildren.19947987103
gastric lymphoma in grampian region: presentation, treatment and outcome.forty cases of gastric lymphoma presenting in grampian region (1974-91) were reviewed to examine the effects of changing ideas in the fields of chemotherapy, gastric surgery and diagnostic techniques, as well as the impact of helicobacter pylori. presentation was non-specific, and the diagnosis was made pre-operatively in only 12 cases. survival was related to tumour size, staging (ann arbor), and grade, with a crude 5-year survival of 49%. helicobacter pylori was found in all specimens reviewed ...19968763174
helicobacter pylori in the mouth--negative isolation from dental plaque and saliva.to determine the colonization of helicobacter pylori in dental plaque and saliva of individuals with h. pylori-associated gastritis.19968900903
gastric fundic gland polyps in south-east scotland: absence of adenomatous polyposis coli gene mutations and a strikingly low prevalence of helicobacter pylori infection.fundic gland polyps (fgp) were originally described in association with familial polyposis syndromes, but it is now accepted that the majority of fgp are picked up incidentally in up to 1.9% of routine endoscopies in dyspeptic patients. the familial adenomatous polyposis phenotype arises from germline mutations of the adenomatous polyposis coli (apc) gene. we aimed to see if there was any association between the presence of fgp, helicobacter pylori, and two common apc gene mutations.200212453274
measurement of plasma viscosity in stored frozen samples: a general population study.to establish whether plasma viscosity could be accurately measured from frozen-stored (instead of fresh) plasma samples in epidemiological studies, we prospectively compared fresh and frozen-stored samples from 1361 men and women aged 25-74 years participating in the glasgow monica survey. mean plasma viscosity (37 degrees c) was significantly higher (p < 0.0001) in fresh samples (mean = 1.310 mpa/s, standard deviation = 0.079 mpa/s) compared with frozen samples (mean = 1.278 mpa/s, standard dev ...200312945886
helicobacter pylori in children is strongly associated with poverty.to examine the association between prevalence of h. pylori colonisation and social deprivation in a sample of children investigated in hospital.200415648706
increase in nf-kappab binding affinity of the variant c allele of the toll-like receptor 9 -1237t/c polymorphism is associated with helicobacter pylori-induced gastric disease.colonization of the gastric mucosa by helicobacter pylori can lead to serious clinical outcomes, including gastric cancer. toll-like receptors (tlrs) play an important role in the host response to h. pylori through the recognition of pathogen-associated molecular patterns. tlr9, in particular, is partly responsible for initiating bacterial induced immunity by binding unmethylated cpg-dna, which is abundant in bacteria. a well-documented single nucleotide polymorphism (snp) within the tlr9 promot ...201020038537
famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (famous): a phase iii, randomised, double-blind, placebo-controlled trial.there are few therapeutic options for the prevention of gastrointestinal mucosal damage caused by low-dose aspirin. we therefore investigated the efficacy of famotidine, a well-tolerated histamine h(2)-receptor antagonist, in the prevention of peptic ulcers and erosive oesophagitis in patients receiving low-dose aspirin for vascular protection.200919577798
are endoscopy nurses at risk of infection with helicobacter pylori from their work?in response to studies suggesting risk of occupational transmission of helicobacter pylori (hp) to endoscopy staff, this cross-sectional study of seroprevalence to hp in gastroscopy nurses working in west of scotland hospitals (an area of high endemicity of hp infection) was performed to determine if they were at excess risk relative to peers working in surgical specialities but without gastroscopy exposure. the study aimed to fulfil employer's duties to carry out a suitable risk assessment requ ...200616390848
an investigation into factors associated with helicobacter pylori infection.this study aims to estimate the prevalence of helicobacter pylori in glasgow, and to provide a systematic analysis of factors associated with this prevalence. the data used are from a random population sample of 793 men and 838 women aged 25-64 years conducted in 1995. the prevalence is estimated to be 66% (95% confidence interval: 63-68%); a level that is more typical of developing countries. prevalence increases with age and social deprivation (p<0.0001) and is slightly higher in men than wome ...200010729690
acute upper gastrointestinal haemorrhage in west of scotland: case ascertainment study.to determine the incidence and case fatality of acute upper gastrointestinal haemorrhage in the west of scotland and to identify associated factors.19979329304
height and risk of death among men and women: aetiological implications of associations with cardiorespiratory disease and cancer mortality.height is inversely associated with cardiovascular disease mortality risk and has shown variable associations with cancer incidence and mortality. the interpretation of findings from previous studies has been constrained by data limitations. associations between height and specific causes of death were investigated in a large general population cohort of men and women from the west of scotland.200010715741
helicobacter pylori eradication for peptic ulceration: an observational study in a scottish primary care setting.despite being established for the treatment of peptic ulcer (pu) disease, few studies have assessed the long-term effectiveness and economic benefits of helicobacter pylori (hp) eradication in primary care. our aim was to investigate the effect of community based hp eradication for patients with chronic peptic ulcer disease requiring maintenance acid suppression. the endpoints used were the patients dyspeptic symptoms and the requirement for the prescription of maintenance acid suppression thera ...200212058660
rising trends of gastric cancer and peptic ulcer in the 19th century.the risk of dying from gastric cancer appears to have increased among consecutive generations born during the 19th century. aim: to follow the time trends of hospitalization for gastric cancer and test whether they confirm such increase.201020659282
helicobacter pylori infection and coronary heart disease in the north glasgow monica population.recent evidence suggests that helicobacter pylori infection is associated with coronary heart disease. we investigated whether h. pylori infection is related to prevalent coronary heart disease, in a random sample of 1428 men and women aged 25-74 years.19979458417
the glasgow dyspepsia severity score--a tool for the global measurement of dyspepsia.there is currently no reliable tool for providing a global measurement of the severity of dyspepsia in patients with a variety of upper gastrointestinal disorders. we have designed a questionnaire which records frequency of symptoms, effect on routine activities, time off work, frequency of medical consultations, clinical investigations and use of over-the-counter and prescribed medications. the objective of the paper was to assess this questionnaire with respect to reproducibility, validity, re ...19968930560
eradication of helicobacter pylori in general practice.to determine the current management of patients with helicobacter pylori infection in general practice with regard to the selection of patients, testing for the presence of the organism, the choice of eradication therapy and the occurrence of symptoms during follow-up.19968730241
the prevalence of helicobacter pylori infection in patients with intestinal metaplasia and in controls: a serological and histological study in four united kingdom centres. the uk sub-group, the ecp-euronut intestinal metaplasia study group. 19947735051
prospective relations between helicobacter pylori infection, coronary heart disease, and stroke in middle aged men.to determine whether helicobacter pylori, a chronic bacterial infection often acquired in childhood, is associated with increased risk of coronary heart disease and stroke later in life.19968697158
upper gastro-intestinal disease in scotland: a survey of practice amongst scottish gastroenterologists.given the range of causes of upper gastrointestinal disease (ugd), the evolving role of helicobacter pylori in its pathogenesis and the variety of treatments available, one might expect complex management strategies in the management of these diseases. the aim of this study was to determine the current management strategies used in peptic ulcer disease and gastritis in scotland and to identify areas where large and clinically important variations in practice exist between gastro-intestinal speci ...19968908952
the prevalence of dyspepsia and use of antisecretory medication in north glasgow: role of helicobacter pylori vs. lifestyle factors.to determine the prevalence of dyspepsia and associated antisecretory medication usage, and their associations with h. pylori infection in the general population. in addition, to compare the importance of h. pylori infection relative to other potential causes of dyspepsia: alcohol, smoking and obesity.199910571608
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