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chikungunya virus arthritis in adult wild-type mice.chikungunya virus is a mosquito-borne arthrogenic alphavirus that has recently reemerged to produce the largest epidemic ever documented for this virus. here we describe a new adult wild-type mouse model of chikungunya virus arthritis, which recapitulates the self-limiting arthritis, tenosynovitis, and myositis seen in humans. rheumatic disease was associated with a prolific infiltrate of monocytes, macrophages, and nk cells and the production of monocyte chemoattractant protein 1 (mcp-1), tumor ...201020519386
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