| preliminary laboratory report of fungal infections associated with contaminated methylprednisolone injections. | in september 2012, the centers for disease control and prevention (cdc) initiated an outbreak investigation of fungal infections linked to injection of contaminated methylprednisolone acetate (mpa). between 2 october 2012 and 14 february 2013, the cdc laboratory received 799 fungal isolates or human specimens, including cerebrospinal fluid (csf), synovial fluid, and abscess tissue, from 469 case patients in 19 states. a novel broad-range pcr assay and dna sequencing were used to evaluate these s ... | 2013 | 23761142 |
| multistate outbreak of fungal infection associated with injection of methylprednisolone acetate solution from a single compounding pharmacy - united states, 2012. | on september 18, 2012, the tennessee department of health was alerted by a clinician regarding a patient with culture-confirmed aspergillus fumigatus meningitis diagnosed 46 days after epidural steroid injection at a tennessee ambulatory surgical center. by september 27, the initial investigation, carried out by the tennessee department of health in collaboration with cdc and the north carolina department of health and human services, had identified an additional eight patients with clinically d ... | 2012 | 23076093 |
| aspergillus fumigatus sternal wound infections in patients undergoing open heart surgery. | during a 21-month period (july 1986-april 1988), six patients who underwent open heart surgery at holston valley hospital and medical center in kingsport, tennessee, developed sternal would infections caused by aspergillus fumigatus. all patients required sternectomy, reconstructive surgery, and long term amphotericin b therapy; no patient died. by univariate analysis, the following were significantly associated with a. fumigatus sternal would infection: chronic lung disease, a recent history of ... | 1992 | 1736660 |
| fungal infections associated with contaminated methylprednisolone in tennessee. | we investigated an outbreak of fungal infections of the central nervous system that occurred among patients who received epidural or paraspinal glucocorticoid injections of preservative-free methylprednisolone acetate prepared by a single compounding pharmacy. | 2012 | 23131029 |
| invasive aspergillosis in renal transplant recipients: correlation with corticosteroid therapy. | during a 31-month period in 1979-1981, nine patients at a renal transplant center in tennessee developed invasive infections with aspergillus species. despite an extensive search, no common environmental source of contamination was found. a matched case-control study of host risk factors showed that leukopenia, prior administration of antibiotics, and treatment with azathioprine and antilymphocyte serum were not significantly related to the development of aspergillosis. in contrast, the administ ... | 1983 | 6350492 |