| molecular epidemiology of dengue in the pacific: introduction of two distinct strains of dengue virus type-1 [corrected] into hawaii. | in 2000, a major dengue epidemic, caused by the type-1 virus (denv-1), began in the pacific and asia, with cases still being reported in 2006. the phylogenetic analysis of full-length sequences of the envelope-protein gene of denv-1 isolates recovered during outbreaks in hawaii and tahiti in 2001-2002 indicated that most hawaiian isolates were tahitian in origin. all the hawaiian and tahitian isolates were identified as the pacific subtype (i.e. subtype iv) of denv-1. a hawaiian isolate, collect ... | 2006 | 16762113 |
| differential functional avidity of dengue virus-specific t-cell clones for variant peptides representing heterologous and previously encountered serotypes. | proinflammatory cytokines secreted by memory cd8+ and cd4+ t cells are thought to play a direct role in the pathogenesis of dengue virus infection by increasing vascular permeability and thereby inducing the pathophysiologic events associated with dengue hemorrhagic fever and dengue shock syndrome. severe disease is frequently observed in the setting of secondary infection with heterologous dengue virus serotypes, suggesting a role for cross-reactive memory t cells in the immunopathogenesis of s ... | 2007 | 17626101 |
| homology of complete genome sequences for dengue virus type-1, from dengue-fever- and dengue-haemorrhagic-fever-associated epidemics in hawaii and french polynesia. | dengue epidemic virulence is thought to be conferred by various factors, including the genotype of the virus involved. increased or decreased epidemic virulence has been associated not only with the introduction of type-2 (denv-2) strains into the south pacific, the caribbean and south america, but also with newly emergent denv-3 genotypes in sri lanka, and the year-to-year variation in the denv-4 strains circulating in puerto rico. these observations indicate that there are inherent differences ... | 2010 | 20507696 |