| long-term memory cellular immune response to dengue virus after a natural primary infection. | this study was conducted to examine the memory t-cell response to dengue virus 20 years after a primary infection. we took advantage of the exceptional epidemiologic situation in cuba, where the population initially suffered two large successive epidemics due to dengue virus 1 and 2 respectively over a 4-year period. thereafter, no dengue virus circulation was subsequently observed, except for the santiago de cuba municipality. | 2002 | 12121600 |
| epidemiologic studies on dengue in santiago de cuba, 1997. | a small, isolated outbreak of dengue hemorrhagic fever/dengue shock syndrome (dhf/dss) due to dengue virus type 2 (den-2) was documented in santiago de cuba on the island of cuba beginning in january 1997. there were 205 dhf/dss cases, all in persons older than age 15 years. all but three had evidence of a prior dengue infection, with the only known opportunity being the islandwide dengue virus type 1 (den-1) epidemic of 1977-1979. virtually complete clinical and laboratory surveillance of overt ... | 2000 | 11085389 |
| invited commentary: dengue lessons from cuba. | an 18-year interval between a dengue virus type 1 outbreak in 1977-1979 and a dengue virus type 2 outbreak in 1997 in santiago de cuba, cuba, provided a unique opportunity to evaluate risk factors for dengue disease. all patients with symptomatic dengue, including 205 cases of dengue hemorrhagic fever and 12 deaths, were adults born before the dengue virus type 1 epidemic, and nearly all (98%) experienced secondary dengue virus infections. in contrast, almost all of those who seroconverted witho ... | 2000 | 11085390 |