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efficacy of a bivalent hpv 16/18 vaccine against anal hpv 16/18 infection among young women: a nested analysis within the costa rica vaccine trial.anal cancer remains rare (incidence of about 1·5 per 100,000 women yearly), but rates are increasing in many countries. human papillomavirus (hpv) 16 and 18 infections cause most cases of anal cancer. we assessed efficacy of an as04-adjuvanted hpv 16 and hpv 18 vaccine against anal infection with hpv 16, hpv 18, or both (hpv 16/18).201121865087
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