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molecular epidemiology of bordetella pertussis by pulsed-field gel electrophoresis profile: cincinnati, 1989-1996.reported cases of pertussis have increased in the united states, with peaks occurring every few years. bordetella pertussis isolates collected in cincinnati from 1989 to 1996 were analyzed with pulsed-field gel electrophoresis (pfge), to evaluate trends. among 496 isolates, 30 pfge profiles were identified; 32% were cyxxi-010, the profile that predominated each year. eighteen profiles (198 strains) were identified in 1989-1992, 20 profiles (197 strains) were identified during the 1993 epidemic, ...200111294667
occurrence of 3 bordetella species during an outbreak of cough illness in ohio: epidemiology, clinical features, laboratory findings and antimicrobial susceptibility.an increase in laboratory diagnosis of pertussis was noted in central ohio during 2010. diagnosis was made using a polymerase chain reaction assay targeting the multicopy insertion sequence is481, which is found in both bordetella pertussis (bp) and bordetella holmesii (bh). an increase in specimens testing positive for bordetella parapertussis (bpp) using insertion sequence is1001 was also noted.201424445823
containment of pertussis in the regional pediatric hospital during the greater cincinnati epidemic of 1993.to describe methods of preventing nosocomial pertussis in patients, employees, and visitors to a hospital during a communitywide epidemic in greater cincinnati.19958568199
the 1993 epidemic of pertussis in cincinnati. resurgence of disease in a highly immunized population of children.in 1993 there was a resurgence of pertussis in the united states. altogether, 6335 cases were reported, the most in 26 years.19948202096
epidemiologic and laboratory features of a large outbreak of pertussis-like illnesses associated with cocirculating bordetella holmesii and bordetella pertussis--ohio, 2010-2011.during 9 may 2010-7 may 2011, an outbreak of pertussis-like illness (incidence, 80 cases per 100 000 persons) occurred in franklin county, ohio. the majority of cases were identified by is481-directed polymerase chain reaction (pcr), which does not differentiate among bordetella species. we sought to determine outbreak etiology and epidemiologic characteristics.201323087388
use of pertussis vaccine in an epidemic involving hospital staff.an epidemic of pertussis occurred among hospital staff caring for paediatric patients. eight physicians and five nurses were affected. pertussis developed in six newborn infants exposed to infected hospital staff in the nursery. erythromycin prophylaxis was used to control the epidemic. clinical pertussis developed in five adults infected with bordetella pertussis before erythromycin was used, whereas symptoms developed in only one of the eight adults who became infected after erythromycin proph ...197551354
a trial of acellular pertussis vaccine in hospital workers during the cincinnati pertussis epidemic of 1993.the safety and immunogenicity of acellular pertussis (ap) vaccine in outbreak control was determined in a randomized, double-blind, controlled trial. participants received ap vaccine (n=102), which contained 25 microg of pertussis toxoid (pt) and 3 microg of filamentous hemagglutinin (fha), or licensed meningococcal vaccine (mn; n=97). local reactions (pain or tenderness, redness, swelling, and induration) and systemic reactions (fever, sleepiness or lethargy, and irritability) were similar amon ...200111528571
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