enhanced ex vivo stimulation of mycobacterium tuberculosis-specific t cells in human immunodeficiency virus-infected persons via antigen delivery by the bordetella pertussis adenylate cyclase vector.the genetically detoxified bordetella pertussis adenylate cyclase is a promising delivery system for immunodominant tuberculosis antigens in gamma interferon release assays. this system has not been evaluated in human immunodeficiency virus (hiv)-infected persons in high tuberculosis prevalence areas. a whole-blood gamma interferon release assay with mycobacterium tuberculosis antigens (early-secreted antigenic target 6, culture filtrate protein 10, alpha-crystallin 2, and tb10.3) delivered by a ...200717522328
maternal hiv infection and antibody responses against vaccine-preventable diseases in uninfected infants.altered immune responses might contribute to the high morbidity and mortality observed in human immunodeficiency virus (hiv)-exposed uninfected infants.201121304083
an outbreak of whooping cough in a highly vaccinated urban 1950 a whole-cell pertussis vaccine was introduced in cape town and was followed by a marked decline in reported whooping cough mortality and morbidity. this resulted in reduced awareness of whooping cough as a clinical problem and, in recent years, no routine diagnostic tests for bordetella pertussis have been performed. an outbreak of whooping cough occurred in cape town between 1 june 1988, and 31 may 1989, with 292 children admitted to hospital for whooping cough during this period (hospi ...19912027168
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