| trial of management of borderline and other low-grade abnormal smears (tombola): trial design. | cervical screening reduces the risk of cervical cancer by detecting and treating cervical intraepithelial neoplasia (cin). the management of women with low-grade cervical abnormalities is controversial. two management policies exist: repeat smears in primary care and colposcopy examination. it is not clear which of these is the more effective and efficient. there is also uncertainty as to the most effective and efficient management of women at colposcopy when an area of abnormality is seen on th ... | 2006 | 16765101 |
| prevalence of type-specific hpv infection by age and grade of cervical cytology: data from the artistic trial. | human papillomavirus (hpv) infection causes cervical cancer and premalignant dysplasia. type-specific hpv prevalence data provide a basis for assessing the impact of hpv vaccination programmes on cervical cytology. we report high-risk hpv (hr-hpv) type-specific prevalence data in relation to cervical cytology for 24,510 women (age range: 20-64; mean age 40.2 years) recruited into the artistic trial, which is being conducted within the routine nhs cervical screening programme in greater mancheste ... | 2008 | 18392052 |
| an analysis of temporal and generational trends in the incidence of anal and other hpv-related cancers in southeast england. | patients diagnosed in 1960-2004 with cancer of the cervix, anus, vulva, vagina or penis were identified from the thames cancer registry database, and age-standardised period (temporal) incidence rates calculated by direct standardisation. age-cohort modelling techniques were used to estimate age-specific incidence rates in the earlier and later cohorts, enabling the calculation of age-standardised cohort (generational) rates. incidence of anal cancer increased for both men and women over the per ... | 2009 | 19156144 |
| long-term follow-up of cervical disease in women screened by cytology and hpv testing: results from the hart study. | several studies have shown that testing for high-risk human papillomavirus (hpv) types results in an improved sensitivity for cin2+, compared with cytology, although with a somewhat lower specificity. | 2010 | 20354519 |
| human papillomavirus vaccine coverage. | | 2010 | 20674714 |
| registrar earns fellowship to research hpv. | | 2010 | 20966992 |
| mavaric - a comparison of automation-assisted and manual cervical screening: a randomised controlled trial. | the principal objective was to compare automation-assisted reading of cervical cytology with manual reading using the histological end point of cervical intraepithelial neoplasia grade ii (cin2) or worse (cin2+). secondary objectives included (i) an assessment of the slide ranking facility of the becton dickinson (bd) focalpoint™ slide profiler (becton dickinson, franklin lakes, nj, usa), especially 'no further review', (ii) a comparison of the two approved automated systems, the thinprep® imagi ... | 2011 | 21266159 |