determinants of moraxella catarrhalis colonization in healthy dutch children during the first 14 months of life.moraxella catarrhalis is an established bacterial pathogen, previously thought to be an innocent commensal of the respiratory tract of children and adults. the objective of this study was to identify significant risk factors associated with m. catarrhalis colonization in the first year of life in healthy dutch children. this study investigated a target cohort group of 1079 children forming part of the generation r study, a population-based prospective cohort study following children from fetal l ...201019681950
colonization of healthy children by moraxella catarrhalis is characterized by genotype heterogeneity, virulence gene diversity and co-colonization with haemophilus influenzae.the colonization dynamics of moraxella catarrhalis were studied in a population comprising 1079 healthy children living in rotterdam, the netherlands (the generation r focus cohort). a total of 2751 nasal swabs were obtained during four clinic visits timed to take place at 1.5, 6, 14 and 24 months of age, yielding a total of 709 m. catarrhalis and 621 haemophilus influenzae isolates. between january 2004 and december 2006, approximate but regular 6-monthly cycles of colonization were observed, w ...201120847012
changes in genetic types and population dynamics of moraxella catarrhalis in hospitalized children are not associated with an exacerbation of existing disease.pulsed-field gel electrophoresis typing was performed on a retrospective set of 129 moraxella catarrhalis isolates obtained over a 20 month period from 70 children admitted to, or presenting at, the erasmus university medical center, rotterdam, the netherlands. the mean age of the children (at the end of the study) was 2.5 years, with a range of 6 months to 15 years. fifty-one different m. catarrhalis types were isolated from the hospitalized children, with 31 % (22/70) being infected with two p ...200312909660
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