long-term impact of pneumococcal polysaccharide vaccination on nasopharyngeal carriage in children previously vaccinated with various pneumococcal conjugate vaccine regimes.previously, the fiji pneumococcal project (fipp) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (pcv7 and 23vppv, respectively). immune hyporesponsiveness was observed in children vaccinated with 23vppv at 12 months of age compared with children who did not receive 23vppv. here we assess the long-term impact of 23vppv vaccination on nasopharyngeal carriage rates and densities of streptococcus pneumoniae, haemophilus in ...201526232540
the effect of pneumococcal vaccination on nasopharyngeal carriage of s. pneumoniae, h. influenzae, m. catarrhalis, and s. aureus in fijian children.the 7-valent pneumococcal conjugate vaccine (pcv7) reduces carriage of vaccine type streptococcus pneumoniae but leads to replacement by non-vaccine serotypes and may affect carriage of other respiratory pathogens. we investigated nasopharyngeal carriage of s. pneumoniae, haemophilus influenzae, moraxella catarrhalis, and staphylococcus aureus in fijian infants participating in a pneumococcal vaccine trial using quantitative pcr. vaccination did not affect pathogen carriage rates or densities, w ...201122170924
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