Publications

epizootiology of chronic wasting disease in free-ranging cervids in colorado and wyoming.	surveillance and epidemic modeling were used to study chronic wasting disease (cwd), a transmissible spongiform encephalopathy that occurs naturally among sympatric, free-ranging deer (odocoileus spp.) and rocky mountain elk (cervus elaphus nelsoni) populations in contiguous portions of northeastern colorado and southeastern wyoming (usa). we used clinical case submissions to identify endemic areas, then used immunohistochemistry to detect cwd-infected individuals among 5,513 deer and elk sample ...	2000	11085429
detection of bias in harvest-based estimates of chronic wasting disease prevalence in mule deer.	diseased animals may exhibit behavioral shifts that increase or decrease their probability of being randomly sampled. in harvest-based sampling approaches, animal movements, changes in habitat utilization, changes in breeding behaviors during harvest periods, or differential susceptibility to harvest via behaviors like hiding or decreased sensitivity to stimuli may result in a non-random sample that biases prevalence estimates. we present a method that can be used to determine whether bias exist ...	2000	11085430
prion gene sequence variation within diverse groups of u.s. sheep, beef cattle, and deer.	prions are proteins that play a central role in transmissible spongiform encephalopathies in a variety of mammals. among the most notable prion disorders in ungulates are scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer. single nucleotide polymorphisms in the sheep prion gene ( prnp) have been correlated with susceptibility to natural scrapie in some populations. similar correlations have not been reported in cattle or deer; however, characterizat ...	2003	14722726
chronic wasting disease of cervids.	chronic wasting disease (cwd) has recently emerged in north america as an important prion disease of captive and free-ranging cervids (species in the deer family). cwd is the only recognized transmissible spongiform encephalopathy (tse) affecting free-ranging species. three cervid species, mule deer (odocoileus hemionus), white-tailed deer (o. virginianus), and rocky mountain elk (cervus elaphus nelsoni), are the only known natural hosts of cwd. endemic cwd is well established in southern wyomin ...	2004	15148993
chronic wasting disease and potential transmission to humans.	chronic wasting disease (cwd) of deer and elk is endemic in a tri-corner area of colorado, wyoming, and nebraska, and new foci of cwd have been detected in other parts of the united states. although detection in some areas may be related to increased surveillance, introduction of cwd due to translocation or natural migration of animals may account for some new foci of infection. increasing spread of cwd has raised concerns about the potential for increasing human exposure to the cwd agent. the f ...	2004	15207045
low frequency of prp genotype 225sf among free-ranging mule deer (odocoileus hemionus) with chronic wasting disease.	the prion protein (prp) gene was characterized in 1482 free-ranging mule deer (odocoileus hemionus) from wyoming and colorado. using dna sequences from 363 deer, dimorphisms at codons 20 (aspartate/glycine) and 225 [serine (s)/phenylalanine (f)] were found; silent changes occurred at codons 131 (tyrosine) and 247 (isoleucine). the remaining samples were surveyed for codon 225 genotype and all were characterized for chronic wasting disease (cwd) infection status. a total of 112 deer with the geno ...	2005	16033959
chronic wasting disease.	until recently, chronic wasting disease of cervids, the only prion disease affecting wildlife, was believed to be geographically concentrated to colorado and wyoming within the united states. however, increased surveillance has unveiled several additional pockets of cwd-infected deer and elk in 12 additional states and 2 canadian provinces. deer and elk with cwd have extensive aggregates of prp(sc) not only in the central nervous system, but also in peripheral lymphoid tissues, skeletal muscle, ...	2007	17223321