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safety and immunogenicity of oral killed whole cell recombinant b subunit cholera vaccine in barranquilla, colombia.in january and february 1992, an assessment was conducted of the safety and immunogenicity of two doses of a new oral cholera vaccine prepared from the recombinant b subunit of the toxin and from killed whole cells (rbs/wc) in 1,165 individuals between the ages of 12 months and 64 years in barranquilla, colombia. this was a randomized, double-blind placebo-controlled study. participants received two doses of either the vaccine or a placebo (killed escherichia coli k12) over a two-week interval. ...19958605522
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