| construction and immunogenicity studies of recombinant fowl poxvirus containing the s1 gene of massachusetts 41 strain of infectious bronchitis virus. | the spike 1 (s1) surface glycoprotein of infectious bronchitis virus (ibv) is the major inducer of the generation of virus neutralizing antibodies, and the administration of purified s1 has been shown to elicit a protective immune response against virulent virus challenge. on the basis of these observations, recombinant fowl poxvirus (rfpv) containing a cdna copy of the s1 gene of ibv mass 41 (rfpv-s1) was constructed and its immunogenicity and vaccine potential were evaluated. initially, rfpv-s ... | 2002 | 12495043 |