| yanucamides a and b, two new depsipeptides from an assemblage of the marine cyanobacteria lyngbya majuscula and schizothrix species. | yanucamides a (1) and b (2) were isolated from the lipid extract of a lyngbya majuscula and schizothrixsp. assemblage collected at yanuca island, fiji. the structures of compounds 1 and 2 were determined by spectroscopic methods. both compounds contain a unique 2,2-dimethyl-3-hydroxy-7-octynoic acid, which has previously been described only as a component of kulolide-1 (3) and kulokainalide-1 (4), metabolites from the marine mollusk philinopsis speciosa. thus, the isolation of the yanucamides fr ... | 2000 | 10691708 |
| somamides a and b, two new depsipeptide analogues of dolastatin 13 from a fijian cyanobacterial assemblage of lyngbya majuscula and schizothrix species. | somamides a (1) and b (2) were isolated from assemblages of the marine cyanobacteria lyngbya majusculaand schizothrix sp. from the fijian islands. these new depsipeptides are analogous in structure to the cyanobacterial metabolite symplostatin 2 (4) as well as dolastatin 13 (3), originally isolated from dolabella auricularia, further demonstrating the cyanobacterial origin of the dolastatins. | 2001 | 11421730 |
| somocystinamide a, a novel cytotoxic disulfide dimer from a fijian marine cyanobacterial mixed assemblage. | [reaction: see text] bioassay-guided investigation of the extract from a lyngbya majuscula/schizothrix sp. assemblage of marine cyanobacteria led to the discovery of somocystinamide a (1), an extraordinary disulfide dimer of mixed pks/nrps biosynthetic origin. somocystinamide a (1) was highly acid-sensitive, rapidly and completely converting to a characterizable derivative (2). compound 1 exhibits significant cytotoxicity against mouse neuro-2a neuroblastoma cells (ic50 = 1.4 microg/ml), whereas ... | 2002 | 11922791 |