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analysis and validation of automated skull stripping tools: a validation study based on 296 mr images from the honolulu asia aging study.as population-based epidemiologic studies may acquire images from thousands of subjects, automated image post-processing is needed. however, error in these methods may be biased and related to subject characteristics relevant to the research question. here, we compare two automated methods of brain extraction against manually segmented images and evaluate whether method accuracy is associated with subject demographic and health characteristics. mri data (n = 296) are from the honolulu asia aging ...200616376107
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