| a nucleotide sequence comparison of coxsackievirus b4 isolates from aquatic samples and clinical specimens. | ten coxsackievirus b4 (cvb4) strains isolated from clinical and environmental sources in northern ireland in 1985-7, were compared at the nucleotide sequence level. dideoxynucleotide sequencing of a polymerase chain reaction (pcr) amplified fragment, spanning the vp1/p2a genomic region, classified the isolates into two distinct groups or genotypes as defined by rico-hesse and colleagues for poliovirus type 1. isolates within each group shared approximately 99% sequence identity at the nucleotide ... | 1993 | 8386098 |