| astrovirus gastroenteritis age distribution of antibody. | astrovirus antibody was detected by immunofluorescence using infected primary human embryo kidney cultures as antigen. of 87 oxford children aged 0--10 years, only 7% in the 6 to 12-month-old group had antibody. the percentage of children having evidence of past infection rose progressively in the 1--4 age range and 75% of the 5 to 10-year-old group possessed astrovirus antibody. fifty-four (77%) of a group of 70 young adults likewise had antibody. | 1978 | 102914 |
| an outbreak of gastroenteritis in a home for the elderly associated with astrovirus type 1 and human calicivirus. | we describe an outbreak of gastroenteritis, which lasted for 22 days in a residential home for the elderly. the outbreak was biphasic and affected 34/42 (80%) residents and 13/29 (44%) members of the staff. calicivirus was associated with cases of illness during the first 9 days of the outbreak, and astrovirus type 1 with cases arising between days 16 to 22. although the symptoms were generally mild, the resources required and the inconvenience caused were considerable. | 1987 | 2826678 |
| the complete sequence of a human astrovirus. | we have determined the complete genomic sequence of human astrovirus serotype 1 isolated in newcastle upon tyne. the genome is 6813 nucleotides long and contains three sequential open reading frames (orfs). the two closest to the 5' end are linked by a ribosomal frameshifting motif and contain sequence motifs indicative of non-structural virus proteins: serine protease and rna-dependent rna polymerase. a nuclear addressing sequence is also located here. the 3' orf encodes the virion structural p ... | 1994 | 8021608 |
| identification of astrovirus serotypes from children treated at the hospitals for sick children, london 1981-93. | an enzyme immunoassay (eia) for astrovirus type 1 together with immune electronmicroscopy (iem) was used to type a collection of 162 astroviruses obtained from 1981-93 from children with diarrhoea. the eia was found to be specific for astrovirus type 1. astrovirus types 2-4 were typed by iem. astrovirus type 1 was the prevalent serotype 107/125 (86%), followed by type 3 (8%), type 4 (6%) and type 2 (1%). six samples containing astrovirus could not be typed or detected by eia because they were co ... | 1994 | 8062872 |
| prevalence of human astrovirus serotypes in the oxford region 1976-92, with evidence for two new serotypes. | results of serotyping on 291 astrovirus-positive stools collected between 1976 and 1992 showed that about two-thirds (64.9%) were serotype 1. infections were more frequent in the fourth quarter of the year and there was a suggestion that during the past 5 years serotype 1 has occurred with greater frequency in alternate years. evidence is provided for the existence of two new serotypes, 6 and 7. | 1994 | 8119358 |
| comparative epidemiology of rotavirus, subgenus f (types 40 and 41) adenovirus and astrovirus gastroenteritis in children. | we report a 5 year prospective study of episodes of rotavirus, subgenus f adenovirus, and astrovirus gastroenteritis diagnosed by electron or immune electron microscopy in a single regional virology laboratory. of 1426 total infections, the numbers in each category were 1117 (78.3%), 254 (17.8%), and 20 (7.9%), respectively. using restriction endonuclease analysis or immune electron microscopy, all but 20 of the subgenus f adenovirus strains were classified as type 40 (n = 50) or type 41 (n = 18 ... | 1993 | 8385704 |
| clinical associations of stool astrovirus in childhood. | from among 1,248 stool specimens examined during the 2-year period, february 1979 to february 1981, astrovirus was detected by electron microscopy in 42 specimens from 28 children. diarrhoea was an invariable clinical feature; vomiting occurred in 18 children, abdominal pain in 7, and mild dehydration in 5. fourteen of the children with acute diarrhoea were admitted directly to the gastroenteritis unit. the other 14 children developed their acute diarrhoea sometime after hospital admission. alth ... | 1982 | 6821117 |
| human astrovirus serotypes. | | 1984 | 6150404 |
| the development and evaluation of radioimmune assays for the detection of immune globulins m and g against astrovirus. | the development and evaluation of radioimmune assays for the detection of igm and igg antibodies to astrovirus are described. the test was shown to be sensitive and specific, and suitable for screening large numbers of sera. the use of the assays has established that astrovirus type 1 is prevalent in the united kingdom and that not only infants but also schoolchildren and elderly patients are affected. further evidence is given to support the view that marin county agent is antigenically related ... | 1988 | 3130387 |
| diversity of enteric viruses detected in patients with gastroenteritis in a tertiary referral paediatric hospital. | the genetic diversity of enteric viruses co-circulating in a cohort of patients with viral gastroenteritis in a large tertiary paediatric hospital in london, uk, was determined. multiple strains of noroviruses (nv), sapoviruses (sv) and astroviruses (hasv) were detected in these patients, indicating the likelihood of multiple introductions from different sources, possible sub-clinical infections and simultaneous infection with different viruses in immunocompromised and other patients. routine sc ... | 2004 | 15170641 |
| seroprevalence of astrovirus types 1 and 6 in london, determined using recombinant virus antigen. | we have developed a microimmunofluorescence test (if) which uses cells infected with a recombinant baculovirus which expresses the capsid proteins of astrovirus types 1 or 6. the if test was sensitive and specific and the results for human astrovirus type 1 (hast-1) were comparable to those obtained by immune electronmicroscopy and radioimmunoassay. application of the test to a panel of 273 sera collected from patients and staff at two childrens hospitals in london showed that over 50% of the po ... | 1996 | 8760964 |
| absence of human astrovirus rna in sewage and environmental samples. | over a period of several weeks during the summer of 1996, samples of sewage, sea water, river water, sand and silt were collected from a sewage works at weston-super-mare, england and from coastal areas nearby. a sensitive reverse-transcriptase polymerase chain reaction (rt-pcr) was used to search for human astrovirus (hastv) rna in concentrates of the samples. no evidence of astrovirus was found in any sample, which suggests that contamination with these viruses is not a problem in this area du ... | 1999 | 10212416 |