| reduced virus replication, proinflammatory cytokine production, and delayed macrophage cell death in human pbmcs infected with the newly discovered bundibugyo ebolavirus relative to zaire ebolavirus. | bundibugyo ebolavirus is a newly identified ebolavirus species. the virus was responsible for a recent hemorrhagic fever outbreak in uganda with an approximate 30% case fatality rate. in this study, we compared the pathogenesis of bundibugyo with highly lethal zaire ebolavirus by using in vitro human pbmcs. we found that pbmcs infected with bundibugyo ebolaviruses resulted in 1 to 2 log lower virus yields compared to zaire ebolavirus and produced 2- to 10-fold lower levels of tnf-alpha, mcp-1, i ... | 2010 | 20394957 |