| genetic changes of coxsackievirus a16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in toyama, japan between 1981 and 2007. | we characterized the genetic diversity of the complete vp1 region of coxsackievirus a16 (ca16) and enterovirus 71 (ev71) isolated from patients with hand, foot, and mouth disease in toyama from 1981 to 2007 to evaluate the relationship between epidemics and genetic changes. the predominant genogroups of ca16 changed from b to c in 1995-1998, and genogroup c further changed from subgenogroup c1 to c2 around 2002, and to c3 in 2005-2007. the subgenogroups of the ev71 isolates were classified into ... | 2009 | 19628900 |