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role for the paramyxovirus genomic promoter in limiting host cell antiviral responses and cell killing.the parainfluenza virus simian virus 5 (sv5) is a poor inducer of innate immune responses. in contrast, the naturally occurring sv5 variant wake forest parainfluenza virus (wf-piv) activates the synthesis of proinflammatory cytokines and beta interferon (ifn-beta). comparison of sv5 and wf-piv genome sequences revealed nine nucleotide differences within the viral genomic promoter, including two substitutions (u5c and a14g) in the most highly conserved 3'-end promoter element. to test the consequ ...200919587032
simian virus 5 is a poor inducer of chemokine secretion from human lung epithelial cells: identification of viral mutants that activate interleukin-8 secretion by distinct mechanisms.we have compared chemokine secretion from human lung a549 cells infected with simian virus 5 (sv5) with other members of the rubulavirus genus of paramyxoviruses. high levels of the chemokines interleukin-8 (il-8) and macrophage chemoattractant protein-1 (mcp-1) were secreted from a549 cells infected with human parainfluenza virus type 2 (hpiv-2) but not from cells infected with wild-type (wt) sv5. the lack of il-8 secretion from sv5-infected cells was not due to a global block in all signal tra ...200312768033
variants of the paramyxovirus simian virus 5 with accelerated or delayed viral gene expression activate proinflammatory cytokine synthesis.our previous results have shown that the parainfluenza virus sv5 is a poor inducer of proinflammatory cytokines interleukin-8 (il-8) and macrophage chemoattractant protein 1 (mcp-1). by contrast, an engineered p/v mutant rsv5-p/v-cpi- and a naturally-occurring variant wf-piv (wake forest-parainfluenza virus) are both potent activators of il-8 and mcp-1. in the present study, we addressed the question of why rsv5-wt is such a poor inducer of host cytokine responses relative to the two sv5 variant ...200616480754
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